In the segment, Kate McKinnon appeared as a fictional "Dr. Wayne Wenowdis" to provide a second opinion on Trump's diagnosis.
As part of her character, McKinnon repeated the phrase "we know this" several times while in conversation with the host Colin Jost about Trump's condition.
McKinnon and Jost eventually burst into laughter. Jost asked: "Kate, are you OK?" She responded: "Obviously, I'm not."
"It's such a crazy time and this is something I started doing to cope," the actress said, turning to the studio audience and Jost. "I have a lot of wigs and mustaches at my disposal, and it's refreshing to play a character who 'know this.'"