Drew Barrymore had her 'first hot flash' on air while interviewing Jennifer Aniston and Adam Sandler: 'I'm so glad I have this moment documented'

• Drew Barrymore was caught off guard after being hit with her first "hot flash" on Monday.
• At the time, the 48-year-old talk show host was interviewing Jennifer Aniston and Adam Sandler.

Drew Barrymore believes she may have experienced her first hot flash while on air.

The 48-year-old actor and talk show host was joined by "Murder Mystery 2" stars Jennifer Aniston and Adam Sandler on Monday's episode of "The Drew Barrymore Show" when she found herself feeling a little flushed.

"I am so hot, I think I'm having my first perimenopause hot flashes," she interrupted her interview with the pair to share.

A hot flash is an uncomfortable rush of heat that can affect your entire body. It's especially common in women over 40. As many as 75% of women around menopausal age experience them.

"For the first time, I think I'm having my first hot flash," she repeated as she took off her blazer and fanned herself. "Whoa!"

"Oh, I feel so honored," Aniston joked as she helped unclip Barrymore's microphone from her blazer to her blouse.

"I'm so sorry, do you feel this?" Barrymore asked as her "He's Just Not That Into You" costar placed a hand on her chest to check her body temperature.

Barrymore then joked that "maybe I'm just that excited" to have Aniston and Sandler on the show.

However, Aniston said that she could feel the "internal heat," while Sandler, who's starred in several movies with both women, reached over to feel Barrymore's hand.

"It's a warm hand," he said, sounding surprised. "Yeah, you got a hot hand."

"That's good because it if was cold, that would be worrisome," Barrymore said. "Well, I'm so glad I have this moment documented."

Sandler then told the host he thought hot flashes often come hand-in-hand with "heavy" mood swings and wondered if that might happen soon.

Barrymore responded by jokingly glaring at him, which made all three burst into laughter.

As Barrymore noted, the timing was a bit uncanny as she "did a panel with Oprah the other day" all about perimenopause and menopause.

"I'm going to show her this clip," Barrymore said.

Meanwhile, Barrymore also sat down with television personality Gayle King last week to speak about their personal experiences with perimenopause as part of the "Facing Fertility" series on "CBS Mornings."

At the time, the "Santa Clarita Diet" star said she had never experienced hot flashes before but said she knew she was perimenopausal — the transition to menopause that often starts around age 40 to 44 — when she "started having my period every two weeks."