<p class="ingestion featured-caption">"Dune: Prophecy" has a big ensemble cast.HBO</p><ul class="summary-list"><li>"Dune: Prophecy" is a prequel series set in the same universe as the "Dune" movies.</li><li>It centers on the origins of the Bene Gesserit, then called the Sisterhood.</li></ul><p>On the heels of <a target="_blank" class href="https://www.businessinsider.com/the-penguin-finale-ending-explained-showrunner-tiktok-mafia-2024-11">"The Penguin" season finale,</a> "Dune: Prophecy" is the next big-budget, IP-driven HBO drama the network is banking on.</p><p>The prequel series is set 10,000 years before the events of Denis Villeneuve's "Dune" movies starring <a target="_blank" class href="https://www.businessinsider.com/timothee-chalamet-put-on-weight-bob-dylan-2024-11">Timothée Chalamet</a>, which together grossed over $1 billion at the global box office. "Dune: Prophecy" focuses on the rise of the Bene Gesserit, a sect of women that secretly seek to control the fate of the Imperium.</p><p>Given the show's place in the "Dune" timeline, viewers won't see familiar faces like Paul Atreides (Chalamet) or Chani (<a target="_blank" class href="https://www.businessinsider.com/every-single-zendaya-movie-ranked-worst-to-best">Zendaya</a>). The big ensemble cast includes new characters (both ones from the book "Dune: Prophecy" is partially based on and original characters created for the show), and it may be hard to keep track of all of them.</p><p>Here's what to know about all the major "Dune: Prophecy" characters, and details to keep in mind while you're watching the show.</p>