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In the years since the series ended, the two actors have remained close and gushed about each other.
Paul called Cranston his "dear friend and mentor" and said that he "would not be the same" without him.
They launched their own Mezcal line called Dos Hombres in 2019 and reprised their "Breaking Bad" roles that year for a Netflix sequel movie called "El Camino."
Paul and Cranston met on the set of AMC's "Breaking Bad," starring as an unlikely drug manufacturing duo.
Aaron Paul and Bryan Cranston on season one of "Breaking Bad."
AMC
Cranston repeatedly pranked Paul into thinking his character was being killed off the show.
Aaron Paul and Bryan Cranston on "Breaking Bad."
AMC
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Over the course of the show's six seasons, the two stars won a total of seven Emmys for their acting.
Aaron Paul and Bryan Cranston at the Emmys in August 2010.
Chris Pizzello/AP
"Breaking Bad" also earned a SAG Award for best television drama series in 2013, much to the delight of the two stars.
Bryan Cranston and Aaron Paul at the Screen Actors Guild Awards on January 27, 2013 in Los Angeles, California.
Michael Buckner/WireImage
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Cranston got a star on the Hollywood Walk of Fame in July 2013, and Paul was on hand to deliver a moving speech about his costar.
Bryan Cranston and Aaron Paul at the actor's Hollywood Walk of Fame ceremony on July 16, 2013 in Los Angeles, California.
Chris Pizzello/Invision/AP
The final episode of "Breaking Bad" aired on September 29, 2013, but it wasn't the last time fans would see Paul and Cranston on-screen together.
Bryan Cranston and Aaron Paul on the series finale of "Breaking Bad."
AMC
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In 2014, "Breaking Bad" won a Golden Globe for best drama TV series, in addition to Cranston's win for best performance by an actor in a drama TV series.
Aaron Paul and Bryan Cranston at the Golden Globes in January 2014.
Jordan Strauss/Invision/AP
Paul called Cranston his "dear friend and mentor" in 2014.
Bryan Cranston and Aaron Paul in September 2013.
Frank Micelotta/Invision for Academy of Television Arts & Sciences/AP
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For Cranston's 60th birthday in March 2020, the actor parodied MTV's "My Super Sweet 16" for "Jimmy Kimmel Live" and was joined by Paul.
Aaron Paul and Bryan Cranston in a skit for "Jimmy Kimmel Live."
ABC
Paul thanked his costar for his "wise words" and friendship in a heartfelt post shared in March 2016.
Aaron Paul and Bryan Cranston in June 2011.
Eric Charbonneau/Invision/AP
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In July 2019, Paul and Cranston revealed that they were launching a Mezcal line called Dos Hombres.
Bryan Cranston and Aaron Paul in July 2013.
Chris Pizzello/Invision/AP
In August 2019, Paul marked his 40th birthday with a lavish 10-day celebration that included Cranston.
Aaron Paul and Bryan Cranston in October 2019.
Jordan Strauss/Invision/AP
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A "Breaking Bad" sequel movie called "El Camino" was released on Netflix in October 2019, featuring the return of Paul as Jesse and a jaw-dropping cameo from Cranston.
Bryan Cranston and Aaron Paul in "El Camino."
Netflix