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While co-stars often share chemistry onscreen, that doesn't mean their personalities mesh in real life.
Conflicting personalities can lead to clashes on and off set. Some co-stars make up after they're done working, while others never become friends. Some celebrities are fired for their fights, while others finish out the project.
Here are 20 pairs of co-stars who allegedly didn't get along on or off set.
Anjelica Oswald contributed to a previous version of this article.
Joan Collins and John Forsythe were not friends off of the "Dynasty" set.
"Dynasty."
ABC
The feud between Bette Davis and Joan Crawford inspired an entire TV series, "Feud: Bette and Joan," in 2017.
Bette Davis and Joan Crawford.
AP Photo
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Julia Roberts and Nick Nolte acted alongside each other in "I Love Trouble," but there was some trouble on set.
"I Love Trouble."
Buena Vista Pictures
Shannen Doherty allegedly didn't get along with her "Charmed" co-star and TV sister Alyssa Milano either.
Milano and Doherty in 1999.
The WB
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Shannen Doherty and Jennie Garth were often at odds on the set of "Beverly Hills, 90210."
Doherty and Garth in 2009.
Fox
Three of the four stars of "Desperate Housewives" got along great — but they reportedly couldn't stand Teri Hatcher.
Felicity Huffman, Marcia Cross, Eva Longoria, and Teri Hatcher in 2004.
ABC
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It wasn't always fine between "X-Files" co-stars and iconic fictional will-they-or-won't-they couple Gillian Anderson and David Duchovny.
Anderson and Duchovny.
Fox
Selma Blair was fired from "Anger Management" after feuding with its star Charlie Sheen.
Sheen and Blair.
FX
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The feud between "Sex and the City" co-stars Kim Cattrall and Sarah Jessica Parker reached fever pitch in 2018.
"Sex and the City."
HBO
Ryan Gosling and Rachel McAdams originally did not get along while filming "The Notebook" — but they went on to date for roughly three years.
Gosling and McAdams in 2005.
New Line Cinema
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Isaiah Washington was fired after inflammatory remarks he made to on-screen best man Patrick Dempsey on the set of "Grey's Anatomy."
Washington and Dempsey.
ABC
Alex Pettyfer confirmed that Channing Tatum wasn't a fan of his when they were filming "Magic Mike," though their characters had a mentor-mentee relationship.
"Magic Mike."
Warner Bros. Pictures
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William Shatner is said to have feuded with basically everyone on the set of "Star Trek."
James Doohan, George Takei, and William Shatner.
Ron Galella, Ltd./Ron Galella Collection/Getty Images
Tom Hardy and Charlize Theron were known for butting heads while filming "Mad Max: Fury Road," much like their characters.
"Mad Max: Fury Road."
Warner Bros. Pictures
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On-screen besties Naya Rivera and Lea Michele famously did not get along on the set of "Glee."
"Glee."
Fox
Janet Hubert was replaced on "The Fresh Prince of Bel-Air" due in part to a feud she had with on-screen nephew Will Smith and on-screen son Alfonso Ribeiro.
"Fresh Prince of Bel-Air."
NBC
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Chad Michael Murray and Sophia Bush kept it professional as co-stars on "One Tree Hill," even after a difficult marriage and divorce.
"One Tree Hill."
The CW
Tyrese Gibson got into a brief feud with "Fast and Furious" co-star Dwayne "The Rock" Johnson after the ninth movie was postponed.
Johnson and Gibson in 2015.
Universal Pictures
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Mariah Carey and Nicki Minaj went at it during their one season as judges on "American Idol."
"American Idol."
Fox
Some believe that a falling out between "Will & Grace" stars Debra Messing and Megan Mullally is to blame for the rebooted sitcom ending after its 11th season.
Mullally and Messing in 2005.
Jon Kopaloff/FilmMagic/Getty Images