17 of the most memorable 'Grey's Anatomy' couples, ranked

Sophia MitrokostasNov 12, 2020, 20:54 IST

Patrick Dempsey and Ellen Pompeo on "Grey's Anatomy."Ron Tom Walt Disney Television via Getty Images

ABC's "Grey's Anatomy" has featured plenty of not-so-great and swoon-worthy couples so far.
Callie and George and George and Izzie were never great romantic matches — they were better as friends.
Jo and Alex had a strong relationship until he left.
Meredith and Derek are the gold standard of great relationships on the show.

Over the last 16 seasons of "Grey's Anatomy," fans have seen a lot of couples begin and end — many of the relationships had fans swooning while others were frustrating to watch.

It's impossible to keep track of all of the relationships that have happened in the nearly two decades since the show premiered, but there have definitely been many that have impacted the show and its characters more than others — and not always in a good way.

Read on for some of the most major "Grey's Anatomy" couples, ranked from worst to best.

Warning: Major spoilers for "Grey's Anatomy" ahead.

George and Callie's relationship never should have happened.

T.R. Knight and Sara Ramirez on "Grey's Anatomy. Scott Garfield/Walt Disney Television via Getty Image

Addison and Derek were always meant to split up.

Kate Walsh and Patrick Dempsey on "Grey's Anatomy. Vivian Zink/Walt Disney Television via Getty Images

George and Izzie had no romantic chemistry.

T.R. Knight and Katherine Heigl on "Grey's Anatomy." ABC

Jackson and Maggie were stepsiblings and lovers.

Jesse Williams and Kelly McCreary on "Grey's Anatomy." Mitch Haaseth/Walt Disney Television via Getty Images

Meredith and Riggs were doomed from the start.

Ellen Pompeo and Martin Henderson on "Grey's Anatomy." Richard Cartwright/Walt Disney Television via Getty Images

Cristina and Owen were never on the same page.

Sandra Oh and Kevin McKidd on "Grey's Anatomy." Danny Feld/Walt Disney Television via Getty Images

Izzie and Denny were perfect, but they didn't exist outside of the hospital.

Katherine Heigl and Jeffrey Dean Morgan on "Grey's Anatomy." Scott Garfield/Walt Disney Television via Getty Images

Amelia and Owen were way too spontaneous.

Caterina Scorsone and Kevin McKidd on "Grey's Anatomy." Mitch Haaseth/Walt Disney Television via Getty Images

Alex and Izzie seemed meant to be — until she left.

Katherine Heigl and Justin Chambers on "Grey's Anatomy." Eric McCandless/Walt Disney Television via Getty Images

Callie and Arizona were great together for a while.

Sara Ramirez and Jessica Capshaw on "Grey's Anatomy." Scott Garfield/Walt Disney Television via Getty Images

Henry and Teddy could have had an amazing life together.

Scott Foley and Kim Raver on "Grey's Anatomy." Ron Tom/Walt Disney Television via Getty Images

Matthew and April ended up together eventually.

Justin Bruening and Sarah Drew on "Grey's Anatomy." Eric McCandless/Walt Disney Television via Getty Images

Miranda and Ben are a pretty healthy example of marriage.

Chandra Wilson and Jason Winston George on "Grey's Anatomy." Mitch Haaseth/Walt Disney Television via Getty Images

April and Jackson had so much potential.

Sarah Drew and Jesse Williams on "Grey's Anatomy." Eric McCandless/Walt Disney Television via Getty Images

Mark and Lexie were there for each other until the end.

Eric Dane and Chyler Leigh on "Grey's Anatomy." Scott Garfield/Walt Disney Television via Getty Images

Alex and Jo are were a perfect match.

Justin Chambers and Camilla Luddington on "Grey's Anatomy." Mitch Haaseth/Walt Disney Television via Getty Images

Meredith and Derek had a wonderful romance.

Patrick Dempsey and Ellen Pompeo on "Grey's Anatomy." Ron Tom Walt Disney Television via Getty Images

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