16 on-screen best friends who reportedly hated each other in real life

Shannen Doherty and Alyssa Milano famously did not get along.The WB

• On-screen chemistry between fictional best friends doesn't always translate to friendship off-screen.
• For every Jennifer Aniston and Courteney Cox success story, there's a heated feud between actors who have to pretend they like each other.
• Rose McGowan recently tweeted that Alyssa Milano made the set of "Charmed" a "toxic AF" work environment.

Acting is a unique profession in which you can find yourself sequestered with your co-workers for 15 hours a day, seven days a week. So it makes sense that personalities clash and drama ensues.

But it's always sad to find out that your BFF goals couldn't actually stand being in a room together, like Julianna Margulies and Archie Panjabi, who played dynamic duo Alicia and Kalinda on "The Good Wife." And what hasn't been said about the legendary falling out of Sarah Jessica Parker and Kim Cattrall on "Sex and the City"?

Here are 16 on-screen besties who reportedly couldn't stand each other off-screen.