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"Friends, delegates and fellow Americans: I humbly and gratefully accept your nomination for the presidency of the United States," Trump said.
Trump's speech hit on many familiar themes, slamming the media and arguing that America "cannot afford to be so politically correct anymore."
It also criticized the Obama administration and presumptive Democratic presidential nominee Hillary Clinton.
The Republican presidential nominee said that Obama regretted appointing Clinton secretary of state, criticizing her foreign policy legacy in countries like Libya and Syria that have been plagued by civil war.
"I am certain it is a decision he truly regrets. Her bad instinct and her bad judgment," Trump said.
He added: "This is the legacy of Hillary Clinton: Death, destruction, terrorism, and weakness."