YouTube/TBS
"At a time when we have heard the worst stories about senseless violence in our country, that it couldn't possibly get worse, the news out of Orlando yesterday is still impossible to fathom," O'Brien said in front of his audience at the start of his show.
And O'Brien allowed the audience a glimpse inside his own political opinions about the issue, something he rarely does on the show. The host took a stand against the selling of automatic rifles to civilians:
"I have really tried very hard over the years not to bore you with what I think. However I am a father of two, I like to believe I have a shred of common sense, and I simply do not understand why anybody in this country is allowed to purchase and own a semi-automatic assault rifle. It makes no sense to me. These are weapons of war and they have no place in civilian life.
"I have tried to understand this issue from every side and it all comes down to this: Nobody I know or have ever met in my entire life should have access to a weapon that can kill so many people so quickly. These mass shootings are happening so often now that lamenting them afterward is becoming a national ritual."
The shooter in Orlando had numerous weapons when he committed the act, including an AR-15 assault rifle.
O'Brien ended his remarks by saying, "It's time to grow up and figure this out."
Watch his full remarks below: