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The Team Sky rider has a four minute five second lead over Frenchman Romain Bardet following a wet penultimate stage in the Alps.
Froome - who has fallen off the bike a couple of times this year and won a couple of stages - will not be tested on the final stage in Paris.
Tradition dictates that the Tour de France race leader isn't challenged on the final stage, meaning Froome will win his third title in four years.
Froome also won the Tour de France in 2013 and 2015.
This year, Froome will take home €500,000 (£417,000) in prize money for his efforts, which is the most he's ever won at the event, according to Total Sportek.
Tour de France prize money has gone up by around 8% this year and there is a total of €2.29 million (£1.98 million) being awarded to riders across the field.
But prize money for the 3,535km three-week race is still relatively low compared to other large sporting events like Wimbledon, where the winners receive a £2 million payout.