Chelsea Handler Leaving E! Talk Show In August

"I myself am more surprised than anyone that I was able to hold down a job for seven years, and it was a fantastic seven years," said Handler, in a prepared statement. "I will always look back at my time on E! as most people look back at their time in college. I'm glad I went."

The late night host's departure marks the first time the time slot will be without a female-led talk show in seven years.

"We are very proud of 'Chelsea Lately's' long-running success and the unique space that the series carved out in late night television," said Suzanne Kolb, president of the network, in a statement. B

But Handler has been increasingly vocal about her desire to leave E! Entertainment.

While on Howard Stern's radio show in March, Handler called E! "a sad, sad place to live," adding, "They don't know what they're doing. They have no ideas. It's a failure."

Handler said on Stern's show that she may want to change mediums to a forum like Netflix, which could be a good move considering her no holds barred sense of humor.