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The company said it may cut costs across Europe to deal with the depreciating Pound and economic uncertainty after the June vote, according to a BBC News report.
General Motors posted record second-quarter earnings on Thursday - $1.86 per share ($1.81 diluted), on net revenue of $42.4 billion - but warned on the prospects in British and European car markets.
Karl-Thomas Neumann, the chief executive of Opel, a GM brand, described Brexit as "not a good omen" for the company in Europe, according to the BBC.
He posted a video on Twitter in which he said the company was "facing strong headwinds at the moment, particularly in our largest market - the United Kingdom."
We're proud of our results in the first half of 2016! A big thank you to all @Vauxhall employees \KTNhttps://t.co/8LczWBNJ3o
- Karl-Thomas Neumann (@KT_Neumann) July 21, 2016
The UK is risking a period of economic uncertainty and the loss of its financial services passport, which can be used by banks based in London to sell services across the EU.
Morgan Stanley CEO James Gorman said this week that his firm would have to launch a new headquarters in Europe. Speaking with CNBC's David Faber about the UK's decision to leave the European Union, Gorman said he recently cut a trip to Germany short to spend time with his employees in London.
"Clearly we and other banks will have to have a European-style headquarters in one of the major markets, whether it's Frankfurt or one of the other cities there," Gorman said.