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The crane collapsed at about noon on the Tappan Zee Bridge, which is under construction to replace the original span built in the 1950s over the Hudson River. It connects Rockland County in the north to New York City's suburbs.
At least three people suffered minor injuries from swerving their cars to avoid colliding with the crashed crane, Rockland County said on Twitter.
NBC News aerial footage showed emergency responders pulling at least two people from cars and one being loaded onto a stretcher. Traffic was backed up for miles, the video showed.
The bridge, which opened in 1955, is the longest in New York state. The nearly $4 billion renovation began in 2013, according to the state's The New NY Bridge website on the project.
Construction is expected to be completed by 2018, according to the website of Tappan Zee Constructors, a consortium of firms working on the project in conjunction with the New York State Thruway Authority.
A number of news outlets and bystanders posted photos and videos of the aftermath on social media:
Crane collapses across Tappan Zee Bridge in New York, but remarkably, no vehicles were hit. https://t.co/5twDSXbw4Khttps://t.co/A3iZoJxXwf
- ABC News (@ABC) July 19, 2016
PHOTOS: Crane collapses on Tappan Zee Bridge in New York #6abc - https://t.co/PPDcIDBiFo pic.twitter.com/Ej7poJdQX0
- Action News on 6abc (@6abc) July 19, 2016
Video from the Tappan Zee Bridge crane collapse courtesy John Hippler pic.twitter.com/JWgoBPeSxm
- RocklandFires (@RocklandFires) July 19, 2016
A crane collapse on New York's Tappan Zee Bridge has closed it indefinitely to traffic. https://t.co/MlTcbZieH1 pic.twitter.com/Rz6opq6mKu
- NBC DFW (@NBCDFW) July 19, 2016