Kalamazoo County Undersheriff Paul Matyas told WOOD-TV that at least nine victims were involved, some of whom may be children. It's not clear whether any of those killed were children.
Matyas said the driver fled on foot after the collision, but has since been arrested.
Witnesses said the bikes and the truck had been moving in opposite directions at the time of the collision.
"I saw a bunch of bikes hit the front of his truck and a couple of them flew," one witness, Markus Eberhard, told WOOD-TV.
According to the National Highway Safety Traffic Administration, 726 cyclists were killed in the US in 2014.