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Grande - whose May 2017 performance in Manchester, England, was devastated by a terrorist bomb explosion that killed 22 people and injured dozens more - tweeted a plea for "love, unity, peace" and "gun control" on Monday.
The 24-year-old singer called for "people to look at this & call this what it is = terrorism."
In June, two weeks after the Manchester attack, Grande returned to Manchester Arena to host a benefit concert honoring the families of the attack's victims.
She now joins the chorus of celebrities mourning the attack, and echoes a number of prominent voices that have called for stricter gun control regulations in its aftermath.
My heart is breaking for Las Vegas. We need love, unity, peace, gun control & for people to look at this & call this what it is = terrorism.
- Ariana Grande (@ArianaGrande) October 2, 2017