1. Bristol-Myers Squibb
Renaissance's biggest holding is its $1.66 billion stake in Bristol-Myers Squibb, a pharmaceuticals giant that makes medicines to treat cancer, HIV/AIDS, cardiovascular disease, diabetes, and other ailments.
Federal regulators approved the company's proposed $74 billion takeover of biotech firm Celgene this month.
2. Chipotle Mexican Grill
Renaissance has a $1.61 billion stake in Chipotle Mexican Grill. The fast-casual Mexican restaurant chain, which has more than 2,500 outlets, has largely recovered from a series of health scares a few years ago.
3. Verisign
Simons and his team have a $1.56 billion stake in Verisign, a network infrastructure group that operates the registry for domains including .com and .net.
4. Celgene
Renaissance has amassed a $1.54 billion stake in Celgene, a biotech firm that develops medicines to treat cancers and inflammatory disorders. Celgene is set to be acquired by Bristol Myers-Squibb, the hedge fund's largest holding.
5. Novo Nordisk
Novo Nordisk is a Danish pharmaceutical company that makes medicines for diabetes, hemophilia, growth disorders, obesity, and other chronic conditions.
Renaissance holds a $1.28 billion stake in the company.
6. Palo Alto Networks
Renaissance holds a $1.19 billion stake in Palo Alto Networks, a cybersecurity group offering firewalls, network security, cloud-based threat analysis, and other software tools to businesses.
7. Biogen
Biogen develops treatments for Parkinson's, Alzheimer's, multiple sclerosis, and other neurological diseases. Renaissance has $983 million worth of Biogen shares.
8. Vertex Pharmaceuticals
Renaissance has a $982 million stake in Vertex Pharmaceuticals, a biotech firm that makes drugs to treat cystic fibrosis, HIV, hepatitis C, cancer, and other ailments.
9. Gilead Sciences
Gilead Sciences makes antivirus drugs to treat HIV, hepatitis, influenza, and other maladies. Renaissance has a $934 million stake in the biopharmaceuticals group.
10. Facebook
Renaissance has amassed $880 million worth of Facebook stock. The social-media titan owns WhatsApp and Instagram as well as Oculus, which makes virtual-reality headsets.