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Notable Mention — "Austin Powers in Goldmember" (2002): $296.7 million. Tom Cruise had a minor role in which he played himself.
(Source: BoxOfficeMojo)
Here are Cruise's top-grossing opening weekends:
1. "War of the Worlds": $65 million
2. "Mission: Impossible II": $58 million
3. "Mission: Impossible III": $48 million
4. "Mission: Impossible": $45 million
5. "Oblivion": $37 million
(Source: BoxOfficeMojo)