RAM is like your computer's back pocket where it keeps things you're currently using handy for the next time you use them. Chrome is a notorious RAM hog, as it keeps all your tabs and websites full of text, images, videos, and ads in your computer's RAM.
To see a list of Chrome processes in order of how much RAM they're using, click the "Memory Footprint" tab. You'll see which tabs, websites, or extensions are using the most RAM, then you can decide whether or not you can close the tab or disable the extension. You can close a tab by simple clicking the "End Task" button on the bottom right of the Chrome Task Manager.
If you're actively using all your tabs and your computer is acting slow, your best bet is to either upgrade your computer with more RAM, or buy a new computer with more RAM than your current computer has. You could also try using your operating system's default web browser, like Microsoft's Edge for Windows and Apple's Safari on macOS. Those are better optimized for your operating system than third-party web browsers like Chrome.