Today, 38-year-old
Here she is looking better than ever at last week's E! upfronts in New York City:
Mike Coppola/Getty
But just three years ago in 2010, Handler's preferred accessory was a cocktail at the "Chelsea Chelsea Bang Bang" book launch party in Beverly Hills:
AP Photo/Dan Steinberg
In 2008, she appeared more modestly dressed at the "Keeping Up with the Kardashians" wrap party:
AP
Handler rocked a newscaster-cut in 2007, the year "Chelsea lately" launched on E!:
Alberto E. Rodriguez/Getty
In 2006, 31-year-old Handler attended the the Las Vegas premiere of "National Lampoon's Cattle Call" flanked between actors Thomas Ian Nicholas and Jenny Mollen:
Ethan Miller/Getty
In 2005, Handler dressed sweetly for the "Rock the Cure" event in Los Angeles:
Mark Mainz/Getty
In 2004 at age 29, Handler starred on Oxygen's "Girls Behaving Badly":
Oxygen/"Girls Behaving Badly"
And just yesterday Handler tweeted this photo of herself as a kid to her nearly 5.4 million followers with the caption "Jersey Sisters," in homage to her hometown: