John F. Kennedy was assassinated in 1963, but he wasn't the only one of his siblings to meet a tragic end.
Kennedy was the second child born to Joseph Kennedy Sr. and Rose Fitzgerald Kennedy. Ultimately, the family would swell to include nine children.
According to Kennedy biographer Alan Brinkley, the politically ambitious Kennedys initially pinned their hopes on their oldest child, Joseph Jr. The two oldest brothers were competitive with one another, but Joseph Jr. always seemed to excel where Kennedy struggled.
Everything changed in 1944, when US Navy pilot Joseph Jr. was killed while flying a secret mission. After that, Brinkley wrote that the second Kennedy son became the "carrier of the family's hopes."
Joseph Jr. wasn't the only Kennedy sibling to die in a plane accident. Kennedy's younger sister Kathleen — who went by the nickname Kick — died in 1948 in a crash in France.
Another one of Kennedy's younger sisters, Rosemary, was born with a mental disability. When she was 23, her parents had her lobotomized, leaving her barely able to walk or speak, according to Irish Central.
Kennedy's two younger brothers both found success in the realm of politics. Robert worked as his older brother's campaign manager and attorney general. He was considered a serious presidential contender before he was assassinated in 1968.
Ted, the youngest Kennedy sibling, was one of the longest-continuously-serving US senators in history. He became embroiled in controversy in 1969 after he drove off a bridge on Chappaquiddick Island. He escaped from the car while his passenger, Mary Jo Kopechne, drowned.
As for Kennedy's other siblings, Eunice went on to become an advocate for those with intellectual disabilities and was an integral figure in founding the Special Olympics. Patricia married actor Peter Lawford and, personality-wise, was notably less competitive than her siblings, according to The New York Times.
Jean Kennedy, the youngest daughter in the family, served as the US ambassador to Ireland. She also wrote a book about her childhood as a Kennedy: "The Nine of Us: Growing Up Kennedy."
"Growing up in a big family of nine children is a less common experience today than it was in those days, and it certainly left its mark on each of us," she wrote.