The first genetic modifications, and broadest sense of the term GMO, has been happening throughout the history of farming.
By picking certain traits, such as bigger fruit, more seeds, and better color, farmers are inherently selecting the genes for certain crops. That’s how the watermelon we eat became so different from versions from the 1600s.
About 300 years ago, farmers and scientists started cross-breeding, or fertilizing new types of plants using two parent plants that wouldn't normally come together in nature. That’s how we get things like potatoes as we know them and many kinds of berries, Bruce Chassy, a professor emeritus of food safety and nutritional science at the University of Illinois, told Business Insider.