AP Photo/Patrick Semansk
It was filmed in and around the city from 2002 to 2008, using its urban grit as a natural backdrop, and it featured local residents as extras and even in small supporting roles.
Five years after the show wrapped, it seems that nothing has changed for Baltimore's poverty-stricken neighborhoods, dark streets and boarded houses.
AP photographer Patrick Semansky captured that state of the city's poorest areas in a photo essay this month.