The bus, reportedly carrying about 40 people, was returning from a summer camp filled with young people from Colonial Hills Baptist Church.
The Star has more:
The large passenger bus overturned on its side near the I-465 overpass, leaving passengers trapped inside.
The accident occurred about 4:15 p.m., and police and rescue workers are still determining the extent of the injuries. Police are closing streets in the area.
The Indianapolis Fire Department told WISH-TV that five passengers were initially trapped inside. Two Lifeline helicopters and 12 ambulances came to the scene and transported patients that were critically injured.
This story is developing, and this post will be updated as we learn more.