AP Photo/Horst Faas, Fil
Born Cassius Marcellus Clay on January 17, 1942, in Louisville, Kentucky, Ali started boxing at age 12 - and ultimately became known for much more than just his successful boxing career.
Ali converted to Islam in 1964, changing his name from Cassius Clay - what he called his "slave name" - to Muhammed Ali after becoming affiliated with the Nation of Islam. His political activism and charity inspired millions throughout his life.
We've compiled some of his now-iconic words of wisdom and trademark boxing ring rhymes.