Let's face it: Steam is ugly.
To change its design, download any Steam skin — there are number of sites where they are available, but PC Gamer has a great list of some particularly nice-looking ones.
You can also make your very own custom skin.
Once you've found a skin you like, open the "Steam" folder (on PC, this folder is usually in "Program Files"), then open the "Skins" folder. Move the file for the skin you downloaded into this folder.
Now, when you restart your Steam client, go to "Settings," then "Interface," and then select the skin you downloaded from the drop-down menu.
To find the "Skins" folder on a Mac, open your "Applications" folder, right-click the Steam icon, and click "Show package contents." Click "Contents," then "MacOS," then "Skins." Drop the downloaded file into this folder.