But many more chief executives escaped assassination attempts thanks to heroic bystanders, diligent guards, misfiring pistols, and crazy luck.
Even two presidents who were eventually assassinated escaped previous attempts on their lives.
On a hot August night in 1864, a sniper shot Lincoln's hat off his head - missing his skull by inches - as he took a solo ride on his favorite horse "Old Abe," according to "1864: Lincoln at the Gates of History." Lincoln was later shot and killed by Confederate sympathizer John Wilkes Booth, just five days after the surrender of Robert E. Lee.
Almost a century later, in 1960, retired postal worker Richard Paul Pavlick crammed his car with dynamite and plotted to ram the vehicle into Kennedy's limo in Palm Beach, Florida, according to Smithsonian magazine. He was motivated by his intense hatred of Catholics and the Kennedy family, but backed off when he saw that the president was with his wife and young children. Pavlick was later arrested and institutionalized until 1966, three years after Kennedy was assassinated by Lee Harvey Oswald while visiting Dallas, Texas.
But these 13 other presidents all experienced serious assassination threats and ultimately survived - and these are only the most dramatic, most-publicized instances. Undoubtedly, the Secret Service has thwarted many more over the years.
Here are 13 presidents who escaped attempts on their lives: