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<keyword id="3658" type="General" weightage="100" keywordseo="india" source="Orion">India</keyword> on Tuesday recorded 3038 fresh cases of covid in the last 24 hours with the active caseload standing at 21,179. The COVID cases in India have seen an upward trend in the past few days with the daily fresh infections ranging between 2,994 on April 1 to 3,824 on April 2 and 3,641 on April 3 now dropped to 3038 in the last 24 hours. With 2,069 recoveries in the last 24 hours, total recoveries have increased to 4,41,77,204. India's recovery rate is currently at 98.76 per cent. The daily and weekly positivity rates are 1.84 per cent and 2.49 per cent respectively. A total of 1,894 doses were administered in the last 24 hours. Of the 92.20 crore total tests conducted so far, 1,64,740 tests were conducted in the last 24 hours. Under the Nationwide Vaccination Drive, India has so far administered 220.65 crore Covid-19 <keyword id="24209" type="General" weightage="80" keywordseo="vaccine" source="Orion">Vaccine</keyword> doses (95.20 crores <keyword id="7334317" type="General" weightage="80" keywordseo="second-dose" source="Orion">Second Dose</keyword> and 22.86 crores <keyword id="12813770" type="General" weightage="80" keywordseo="precaution-dose" source="Orion">Precaution Dose</keyword>), of which 9,497 doses were administered in the last 24 hours. In the wake of rising COVID cases in India, Union Health Minister Mansukh Mandaviya on Monday said that Omicron's sub-variant which is circulating in the country has not led to an increase in hospitalisations and there is no need to worry. The Minister said that there is a need to remain vigilant. "We need to remain alert but there is no need to worry. Currently, the sub-variant of Omicron which is circulating in the country hasn't increased hospitalisations," Mandaviya said. The Ministry of Health and Family Welfare has issued revised guidelines for Covid-19 in the wake of the surge of cases in the past week across the country. "Antibiotics should not be used unless there is clinical suspicion of bacterial infection. The possibility of coinfection of COVID-19 with other endemic infections must be considered. Systemic corticosteroids are not indicated in mild disease," revised guidelines said. "Antibiotics should not be used unless there is clinical suspicion of bacterial infection. The possibility of coinfection of COVID-19 with other endemic infections must be considered. Systemic corticosteroids are not indicated in mild disease," revised guidelines said. "Seek immediate medical attention if difficulty breathing, High-grade fever/ severe cough, particularly if lasting for more than 5 days. A low threshold is to be kept for those with any of the high-risk features," guidelines discussed and prepared in January said. Additionally, in moderate or severe diseases at high risk of progression, the guidelines recommend, "Consider <keyword id="8775508" type="General" weightage="80" keywordseo="remdesivir" source="Orion">Remdesivir</keyword> for up to 5 days (200 mg IV on day 1 followed by 100 mg IV OD for the next 4 days)". SEE ALSO: <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/business/news/virat-kohli-ms-dhoni-rohit-sharma-rule-brand-endorsements-in-indian-sports-industry/articleshow/99237494.cms">With 30 brands each, Kohli, Dhoni &amp; Rohit Sharma rule Indian sports endorsements</a> <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/science/health/news/harsh-discipline-with-young-children-can-lead-to-lasting-mental-health-problems-says-new-study/articleshow/99238367.cms">Harsh discipline with young children can lead to lasting mental health problems says new study</a>

Remain alert says Union Health Minister as India records 3,038 fresh Covid-19 cases

As of now no second Covid-19 booster dose is required, said government sources amid an apparent increase in Covid-19 cases. "First we have to complete the booster drive in the country," said the government sources. India's active caseload currently stands at 2,582, with 134 new cases recorded in the last 24 hours, as per <keyword id="83655" type="General" weightage="80" keywordseo="union-health-ministry" source="Orion">Union Health Ministry</keyword> data. As per ministry data, a total of 220.11 cr vaccine doses (95.13 cr <keyword id="7334317" type="General" weightage="80" keywordseo="second-dose" source="Orion">Second Dose</keyword> and 22.41 cr <keyword id="12813770" type="General" weightage="80" keywordseo="precaution-dose" source="Orion">Precaution Dose</keyword>) have been administered so far under <keyword id="10580665" type="General" weightage="80" keywordseo="nationwide-vaccination-drive" source="Orion">Nationwide Vaccination Drive</keyword>. SEE ALSO: <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/tech/apps/news/series-creators-want-more-money-after-ads-appear-on-netflix/articleshow/96700323.cms">Series creators want more money after ads appear on Netflix</a> <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/thelife/news/pope-benedict-xvi-a-man-at-odds-with-the-modern-world-who-leaves-a-legacy-of-intellectual-brilliance-and-controversy/articleshow/96699003.cms">Pope Benedict XVI: A man at odds with the modern world who leaves a legacy of intellectual brilliance and controversy</a>

No second Covid-19 booster dose required: Govt sources

The ideal time for a <keyword id="2825536" type="General" weightage="20" keywordseo="booster-dose" source="Orion">booster dose</keyword> for COVID-19 vaccine is six months after the second dose, <keyword id="10494595" type="General" weightage="20" keywordseo="Bharat-Biotech-Chairman" source="Orion">Bharat Biotech Chairman</keyword> and Managing Director Krishna Ella said on Wednesday, and also emphasised the importance of having a nasal vaccine. He also pointed out that his company was the first in the world to develop a <keyword id="3225534" type="General" weightage="20" keywordseo="Zika-vaccine" source="Orion">Zika vaccine</keyword>. Taking the <keyword id="9485939" type="General" weightage="50" keywordseo="covaxin" source="Orion">Covaxin</keyword> vaccine by the Prime Minister Narendra Modi showed confidence in Indian Science, he said at the Times Now Summit 2021. "The ideal time for a booster dose is six months after the second dose," Ella stated. <keyword id="149108" type="General" weightage="100" keywordseo="bharat-biotech" source="Orion">Bharat Biotech</keyword> is also looking at nasal vaccine as a booster dose as its scaling up capacity is very easy when compared with Covaxin, he added. About the importance of nasal vaccine, he said the entire world is looking at nasal vaccines. That is the only way to stop transmission. Everyone is trying to figure out the immunology and fortunately, Bharat Biotech has figured it out. "We are coming out with a nasal vaccine, we are thinking that Covaxin can be given as first dose, the second dose can be given a nasal, that is also strategically, scientifically very important because with the second dose, if it is a nasal one, you stop the transmission of the virus...," Ella said. Nasal vaccine works well if someone has been infected or if someone has been vaccinated with one dose, he added. About the PM taking the Covaxin shot, he said, "What would a scientist like to have? A country head taking his vaccine. That is the best satisfaction a scientist can get... It shows confidence in the Indian science, confidence in the startup, and confidence in our innovation...". Speaking about a vaccine for Zika, Ella said Bharat Biotech is ready with a vaccine for Zika virus. Phase I is complete. The government has to take up more trials because there are more cases now. "We were the first company in the world to develop the Zika vaccine in 2014... We were the first one to file for a global patent for Zika vaccine", he added. SEE ALSO: <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/tech/mobile/news/heres-how-you-can-protect-your-smartphone-from-exploding/slidelist/87625685.cms">Here’s how you can protect your smartphone from exploding</a> <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/india/news/union-cabinet-approves-declaration-of-november-15-as-janjatiya-gaurav-diwas/articleshow/87629229.cms">Union Cabinet approves declaration of November 15 as Janjatiya Gaurav Diwas</a>

Ideal time for COVID-19 booster shot is six months after the second dose, says Bharat Biotech MD

Washington, US President-elect <keyword id="99719" type="PERSON" weightage="20" keywordseo="Joe-Biden">Joe Biden</keyword> has received the <keyword id="7334317" type="UNKNOWN" weightage="20" keywordseo="second-dose">second dose</keyword> of the <keyword id="8904563" type="UNKNOWN" weightage="20" keywordseo="covid-19-vaccine">Covid-19 vaccine</keyword>, four weeks after he was administered the first shot. Biden was injected the second dose of the Pfizer-BioNTech vaccine on Monday at a hospital in Newark, Delaware, his home state where his transition headquarters are based, He received the first dose on December 21, 2020. Wearing a short-sleeved polo shirt so that the jab can be easily injected into his arm, Biden urged Americans to continue wearing masks, waving a black one of his own. Taking to Twitter, he said: "Folks, I just received the second dose of my Covid-19 vaccine  and just like the first dose, it was safe, quick, and painless. "I urge everyone to get vaccinated once it's your turn. Because only together can we save lives and beat this virus. "Getting America vaccinated will be one of the greatest operational challenges we've ever faced, but my administration will spare no effort to get it done. "We're going to ensure the vaccine is distributed quickly, equitably, and free of charge to every American." The Pfizer vaccine, which, together with the <keyword id="4912868" type="LOCATION" weightage="20" keywordseo="moderna">Moderna</keyword> vaccine, is being distributed across the country after gaining emergency use authorization -- requires two doses to be injected several weeks apart. So does the Moderna vaccine. Biden has recently vowed to release nearly all of the coronavirus vaccines the country now possesses after taking office on January 20, rather than withhold millions of vials to guarantee second doses are available. He also plans to get 100 million Americans vaccinated in his first 100 days in office. While the rollout of vaccines under the administration of outgoing President Donald Trump has been heavily criticised for being so slow that it failed to hit the initial target of delivering 20 million doses by the end of last year, Biden's plan seems to remain fluid, as reports surfaced that the President-elect vented frustration over the under-performance of his own transition team. Asked about his disappointment, Biden shrugged off those concerns by expressing confidence in his coronavirus task force. "I'm confident we can get done what we have to get done," said the President-elect, reiterating that some 3,000 to 4,000 Americans dying of the virus per day is "beyond the pale." Transition officials have complained about the lack of long-term planning by the Trump administration on immunizing the American people. The US distributed some 25.5 million vaccine doses as of Monday morning, and administered nearly 9 million first doses, according to data from the Centers for Disease Control and Prevention. The country still leads by a big margin in confirmed cases worldwide, now at 22,612,384, more than doubling the number in second-placed India, according to Johns Hopkins University. The death toll has increased to 376,051, also the highest in the world. SEE ALSO: <a href="https://www.businessinsider.in/business/telecom/news/employment-opportunities-in-the-telecom-sector-are-expected-to-grow-by-20-in-2021/articleshow/80183579.cms">Fiber layers and field engineers to researchers ⁠— telecom jobs may see a 20% spike in 2021 as India leaps into the 5G era</a> <a href="https://www.businessinsider.in/budget/news/india-may-be-considering-a-covid-cess-on-high-income-earners-aside-from-more-levy-on-fuel/articleshow/80208520.cms">India may be considering a COVID cess on high income earners — aside from more levy on fuel</a> <a href="https://www.businessinsider.in/tech/apps/news/with-whatsapp-popularity-hit-zoho-plans-to-launch-arattai-messaging-app/articleshow/80206802.cms">Zoho plans to woo WhatsApp defectors with its own messaging app Arattai</a>

US President-elect Joe Biden receives second dose of COVID-19 vaccine

New Delhi, As India gets readied for a <keyword id="10424473" type="UNKNOWN" weightage="20" keywordseo="massive-covid-vaccination-programme">massive Covid vaccination programme</keyword>, heath experts on Sunday said that 21 days is an ideal gap between the first and the <keyword id="10424474" type="UNKNOWN" weightage="20" keywordseo="second-booster-dose">second booster dose</keyword>, and those who get vaccinated have to maintain the same health hygiene as they are supposed to do sans vaccine for a certain time period. Union Health Ministry Secretary Rajesh Bhushan had said that 30 crore people have been listed in prioritised population groups, which involves one crore healthcare workers, two crore personnel from the police department, armed forces, home guard, civil defence organisation and 27 crore people above the age of 50 and below 50 with co-morbidities. The government is expected to roll out its <keyword id="9849917" type="UNKNOWN" weightage="20" keywordseo="first-vaccines">first vaccines</keyword> in the next few weeks with at least three candidates under the <keyword id="6681091" type="UNKNOWN" weightage="20" keywordseo="active-consideration">active consideration</keyword> of India's drug regulator. According to Dr Manoj Goel, Director, Pulmonology at Fortis Hospital in Gurugram, after taking the first dose, the second dose has to be ideally taken on the 21st day. "After the vaccination, one can resume their normal day to day activities. In between also, there are no guidelines to sit at home and people can carry on their usual activities by taking the basic precautions like social distancing, wearing a mask and frequent sanitising of hands," Goel told IANS. The Union Health Ministry had said that 1.54 lakh vaccinators or auxiliary nurse midwives will administer the <keyword id="8763838" type="UNKNOWN" weightage="20" keywordseo="covid-19">Covid-19</keyword> vaccine to people under the universal immunisation programme when the vaccination process begins. According to Dr Jyoti Mutta, Senior Consultant, Microbiology at Sri Balaji Action Medical Institute in New Delhi, there are a number of vaccines which have different schedules and these vaccine schedules are determined by clinical trials. "Talking about Pfizer vaccine in this regard, two doses are suggested 21 days apart and two doses 28 days apart for AstraZeneca vaccine. Also, the proper rest and precautions are suggested during this period in order to avoid infection and proper care," she told IANS. Dr Mutta also stressed that staying at home is not particularly defined as a precautionary measure but complete care is recommended. "Taking precautions like wearing a mask, social distancing and hand hygiene is important to avoid infection," she noted. Dr Neha Gupta, Infectious Diseases Physician at Medanta Hosptial in Gurugram told IANS: "Vaccine requires two doses 21 days apart and usually the protective efficacy is seven days after the second dose. So, patients need to continue precautions after the first dose of vaccine." There are as many as eight <keyword id="8983421" type="UNKNOWN" weightage="20" keywordseo="Covid-vaccine">Covid vaccine</keyword> candidates under different stages of clinical trials which could be ready for authorisation in near future. The vaccines include Covaxin, Astrazeneca and Oxford university developed and Serum Institute of India manufactured <keyword id="9617748" type="COMPANY" weightage="20" keywordseo="covishield">Covishield</keyword>, ZyCoV-D by Zydus Cadila, Russian vaccine candidate Sputnik-V, NVX-CoV2373 by SII, HGCO19 by Geneva, and two unlabelled vaccines - Recombinant Protein antigen-based vaccine by Biological E Limited and Inactivated rabies vector platform by <keyword id="7330627" type="COMPANY" weightage="20" keywordseo="Bharat-Biotech-Limited">Bharat Biotech Limited</keyword>. Pune-based Serum Institute of India and Hyderabad-based pharmaceutical firm Bharat Biotech have already applied to the Drugs Controller General of India (DCGI) seeking emergency use authorisation for their potential Covid-19 vaccines. SEE ALSO: <a href="https://www.businessinsider.in/science/space/news/dos-and-donts-during-solar-eclipse-surya-grahan/articleshow/76436997.cms">The do’s and don’ts of a Solar Eclipse — here what you need to know to protect yourself</a> <a href="https://www.businessinsider.in/science/space/news/solar-eclipse-december-2020-time-date-everything-you-need-to-know/articleshow/79697355.cms">The total solar eclipse and its 'diamond rings' won't be visible in India on December 14</a>

Experts believe COVID-19 vaccine doses need a at least a 21-day gap between them

<ul class="summary-list"><li>Lyme disease can be debilitating; symptoms can range from mild to life-threatening. </li><li>Two pharmaceutical companies, Pfizer and Valneva, are developing a vaccine to prevent Lyme disease in people ages 5 and up. </li></ul>Mindi Weidow vividly remembers the moment she found her first tick. She was getting undressed after a hike in woodsy Pennsylvania and found a tiny, pinhead-sized critter nestled near the bottom of her legging in the warm, snug spot where her pant leg met her ankle.The tick had not burrowed too far into her skin yet, and she was <a href="https://www.insider.com/how-to-check-for-tick-bites-this-summer-2023-5">able to pull it off</a> without too much hassle.Her father, however, was not so lucky.Several years ago, a tick burrowed its way under his skin, and unleashed a nasty form of the borrelia bacteria into his blood. It wasn't until around two months later that lab tests confirmed he had Lyme disease. Weidow's father was then treated with antibiotics, but he still weathers arthritic flare ups and inflammation to this day, symptoms of <a href="https://www.cdc.gov/Lyme/postlds/index.html" target="_blank" rel="noopener">what the CDC has deemed Post-Treatment Lyme Disease</a>. Now, Weidow is hoping that an experimental series of injections she's received might help her avoid the same fate. She is a participant in Pfizer's Vaccine Against Lyme for Outdoor Recreationists trial, or VALOR, the only late-stage lyme disease <a href="https://www.cdc.gov/lyme/prev/vaccine.html#:~:text=Clinical%20trials&amp;text=Valneva%20and%20Pfizer%20have%20developed,A%20(OspA)%20of%20Borrelia." target="_blank" rel="noopener">vaccine trial</a>. If successful, the VALOR trial could herald <a href="https://www.businessinsider.com/lyme-disease-vaccine-what-happened-lawsuits-conspiracy-theories-2021-11">a brand new way to prevent lyme disease</a>, the widely underdiagnosed condition that may impact up to<a href="https://www.cdc.gov/lyme/datasurveillance/index.html#:~:text=Recent%20estimates%20using%20other%20methods%20suggest%20that%20approximately%20476%2C000%20people%20may%20get%20Lyme%20disease%20each%20year%20in%20the%20United%20States" target="_blank" rel="noopener"> 500,000 Americans</a> every year, and can lead to chronic, debilitating pain — and in rare cases, even <a href="https://www.insider.com/25-year-old-man-died-misdiagnosed-lyme-disease-infected-heart-2023-2">death</a>.<h2>Lyme disease can impact the body and brain</h2><div type="image" title="Lyme Disease Rash" height="600" width="800" msid="101319098" hostid="261" sizebytes="54678"></div>Researchers estimate that roughly <a href="https://www.insider.com/lyme-disease-symptoms-treatment-research-tick-bullseye-rash-2022-6?utm_medium=referral&amp;utm_source=yahoo.com">15% of the world</a> has had Lyme disease at some point. Symptoms can range from near imperceptible and flu-like at first, to <a href="https://www.cdc.gov/lyme/treatment/lymecarditis.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Flyme%2Fsigns_symptoms%2Flymecarditis.html" target="_blank" rel="noopener">life-threatening heart problems</a>. The condition isn't always simple for blood tests to pinpoint, because people often test negative early on. Contrary to popular belief, there is not always a <a href="https://www.insider.com/25-year-old-man-died-misdiagnosed-lyme-disease-infected-heart-2023-2">visible bull's-eye rash</a> on the skin from a tick bite.Once the borrelia bacteria have invaded the bloodstream, Lyme infections can spread from the skin to other areas of the body, impacting the immune system and leading to a wide array of non-specific symptoms. Patients with Lyme are often misdiagnosed with other conditions like chronic fatigue syndrome, also known as myalgic encephalomyelitis.In addition to physical symptoms, Lyme can also cause neuropsychiatric issues. <a href="https://www.columbiapsychiatry.org/news/lyme-disease-heightens-risk-mental-disorders-suicidality" target="_blank" rel="noopener">Studies have documented</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7943444/" target="_blank" rel="noopener">neurological issues</a> associated with the disease, including paranoia, depression, <a href="https://www.ninds.nih.gov/health-information/disorders/lyme-disease-neurological-complications" target="_blank" rel="noopener">visual disturbances</a>, and <a href="https://www.insider.com/woman-dies-by-suicide-after-long-battle-with-lyme-disease-2022-9">suicidality</a>. <h2>Could four shots prevent Lyme disease for good?</h2>Currently, there is no vaccine licensed to prevent Lyme disease in people, only shots <a href="https://www.merck-animal-health-usa.com/nobivac/nobivac-lyme/nobivac-lyme-vaccine" target="_blank" rel="noopener">for dogs</a>. <a href="https://www.businessinsider.com/lyme-disease-vaccine-what-happened-lawsuits-conspiracy-theories-2021-11">One human Lyme shot was briefly released years ago by vaccine-maker GSK</a>. Although studies showed it was about 75% effective at stopping Lyme disease, it received a lukewarm public reception and was the subject of conspiracy-theory lawsuits, driving down sales and leading it to be quickly taken off the market.But now there are skyrocketing numbers of Lyme infections in both the US and Europe, and an <a href="https://www.insider.com/new-tick-diseases-emerging-in-us-asia-heartland-bourbon-sftv-2022-6?utm_medium=referral&amp;utm_source=yahoo.com">expanding range of tick</a> territory due to climate change, making <a href="https://time.com/6287950/worst-tick-season-ever/" target="_blank" rel="noopener">2023 potentially the worst tick season on record yet</a>. So Pfizer and its partner — French pharmaceutical-maker Valneva — have decided to try again.Pfizer and Valneva's Lyme vaccine is a series of three initial shots plus one booster jab, delivered about a year later. There are about <a href="https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-valneva-initiate-phase-3-study-lyme-disease" target="_blank" rel="noopener">6,000 trial participants</a> testing out the vaccine across Lyme-prevalent areas of the US, as well as European countries where Lyme-carrying ticks live, including Germany, Sweden, and Poland.The trial hasn't been without its hiccups. About half of the trial sites in the US were originally run by a private clinical research company called Care Access, but in February <a href="https://valneva.com/press-release/pfizer-and-valneva-issue-update-on-phase-3-clinical-trial-evaluating-lyme-disease-vaccine-candidate-vla15/" target="_blank" rel="noopener">Valneva said in a statement</a> that Pfizer was shutting those trial sites down early, due to violations of Good Clinical Practice (GCP) procedures. Care Access <a href="https://careaccess.com/about/news/2023-02-17-statement-about-pfizers-decision-to-discontinue-valor-study-participants" target="_blank" rel="noopener">said in a statement</a> at the time that it did not agree with Pfizer's decision, and that the company was sharing information with the FDA about the case "to ensure they have the facts." Pfizer declined Insider's request for comment on those specific events, but said in an email that "we will continue to enroll participants and carry out the study."<h2>Fishermen, hunters, and biologists are already lining up for this vaccine</h2><div type="image" title="tick biting person" height="1455" width="1940" msid="101319099" hostid="261" sizebytes="93610"></div>Weidow, who is enrolled at an independent trial site that is still up and running, received her first injection last August, then a second shot in November, and her third in April. She hopes it was all the real deal Lyme vaccine, but it's also possible she got fake placebo jabs. She remembers feeling "a little bit of soreness" and "a little bit of fatigue" after her vaccinations, which her trial administrators say are some of the most typical side effect complaints, along with low-grade fevers. She'll go back next year for her final booster shot.Then, the study investigators will wait to see what happens. If Weidow or her boyfriend, who's also enrolled in this trial, notice any new tick bites during the course of the study, which is set to continue through 2025, they've been instructed to keep the tick and bring it in for inspection. This is so vaccine researchers can determine whether or not the participants might've been exposed to Lyme-causing bacteria, and assess how well the vaccine may be working. At the Pennsylvania clinic where Weidow gets her vaccines, roughly 200 trial participants from age 6 to over 90 have enrolled, with more expected to sign up this summer. So far, vaccine-takers have been a mix of outdoor enthusiasts like fisherman, paddlers, and hunters, as well as biology professors and landscapers. In short — almost anyone who lives, works, or has fun around ticks is eligible to try out this vaccine. "Ticks are always a concern in our area," Dr. Alan Kivitz, who runs Weidow's trial at Altoona Center for Clinical Research, told Insider.Weidow said she is looking forward to a day when, maybe, some of that apprehension could be resolved by a vaccine."For me personally, it relieves some of the stress and anxiety of making sure that you do that check the second you get home," she said.

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Remain alert says Union Health Minister as India records 3,038 fresh Covid-19 cases

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No second Covid-19 booster dose required: Govt sources

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Ideal time for COVID-19 booster shot is six months after the second dose, says Bharat Biotech MD

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US President-elect Joe Biden receives second dose of COVID-19 vaccine

IANS

Experts believe COVID-19 vaccine doses need a at least a 21-day gap between them

IANS

A woman is trying out a 4-dose Lyme disease vaccine as we approach the worst summer for ticks yet

Hilary Brueck

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