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A new genetic mutation may be the cause of severe cases of <keyword id="22374" type="General" weightage="80" keywordseo="childhood" source="Orion">childhood</keyword> <keyword id="109031" type="General" weightage="100" keywordseo="glaucoma" source="Orion">glaucoma</keyword>, a debilitating condition that runs in families and can cause children to lose their vision by the age of three, according to a study.<br /><br />  The discovery was made by an international team of researchers led by Mass Eye and Ear, a division of Mass General Brigham, and Boston Children's Hospital and the findings were published in the Journal of Clinical Investigation.<br /><br /> Through advanced genome-sequencing technology, the researchers found a mutation in the thrombospondin-1 (THBS1) gene in three ethnically and geographically diverse families with childhood glaucoma histories. The researchers then confirmed their findings in a mouse model that possessed the genetic mutation and went on to develop symptoms of glaucoma driven by a previously unknown disease mechanism.<br /><br /> The new findings, could lead to improved screening for childhood glaucoma and earlier and more targeted treatments to prevent vision loss in children with the mutation, according to the study's authors.<br /><br /> "This is a very exciting finding for families affected by childhood glaucoma," said Janey L. Wiggs, MD, PhD, Associate Chief of Ophthalmology Clinical Research at Mass Eye and Ear and the Vice Chair for Ophthalmology Clinical Research and <keyword id="15693489" type="General" weightage="50" keywordseo="paul-austin-chandler" source="Orion">Paul Austin Chandler</keyword> Professor of Ophthalmology at <keyword id="20988" type="General" weightage="50" keywordseo="harvard-medical-school" source="Orion">Harvard Medical School</keyword>. "With this new knowledge, we can offer genetic testing to identify children in a family who may be at risk for the disease and start disease surveillance and conventional treatments earlier to preserve their vision. In the future, we would look to develop new therapies to target this genetic mutation."<br /><br /> Leading cause of childhood blindness<br /><br /> Childhood, or congenital, glaucoma is a rare but serious disease that presents in children as early as birth and as late as 3 years of age. Despite its rarity, childhood glaucoma is responsible for 5 percent of cases of child blindness worldwide.<br /><br /> Glaucoma causes irreversible damage to the eye's optic nerve, often due to buildup of pressure inside the eye (intraocular pressure, or IOP). In adults, this damage can occur over time without symptoms, which is why the disease is often referred to as a "sneak thief of sight."<br /><br /> Children and babies with childhood glaucoma, however, can be born with severe disease and vision loss or lose their vision later in childhood due to elevated IOP. This increase in pressure not only damages the optic nerve but can also affect other structures in a child's eye like the cornea. Children with childhood glaucoma typically require surgeries as early as the first three to six months of life, followed by several more operations throughout their childhood.<br /><br /> With childhood glaucoma, there is typically a strong hereditary component often with multiple members of a family affected by the condition. According to Dr. Wiggs, by better understanding the genes involved, genetic testing can give affected families peace of mind to learn whether their child might be at risk for developing the disease.<br /><br /> Uncovering the genetic underpinnings of disease<br /><br /> For decades, researchers have turned towards genetics to better understand the cause of glaucoma. When Dr. Wiggs first began this line of research 30 years ago, scientists were only able to identify regions of the genome affected in glaucoma. Thanks to advances in genomic technology, researchers gained the ability to review the complete genetic makeup of individuals with and without glaucoma to determine which specific genetic mutations play a role in the disease. Research led by Dr. Wiggs in 2021 used a dataset of more than 34,000 adults with glaucoma to identify 127 genes associated with the condition.<br /><br /> To better study the genetic mutations in childhood glaucoma, Dr. Wiggs and her Mass Eye and Ear team first looked at exome sequences from an American family of European-Caucasian descent who had been part of an earlier research project and found a striking and novel variant in thrombospondin-1, a well-known protein in the body involved in a number of important biological processes, such as the formation of new vessels (angiogenesis) and tissues. This mutated gene was not found in people without childhood glaucoma, nor in large population genetic databases. The amino acid altered by the mutation was evolutionarily conserved, indicating an important role in the protein function. This finding led Dr. Wiggs to connect with colleagues at Flinders University in Australia to see if they had any childhood glaucoma families with thrombospondin mutations. They surprisingly found two families with an alteration at the same amino acid: one of mixed European and Indian descent, and one Sudanese family originally from Africa.<br /><br /> "What was really striking about this finding is that these families all possessed this genetic variant, and it was not possible for them to be related because they were from such diverse backgrounds," said Dr. Wiggs. "That meant there was something really important about this mutation."<br /><br /> To further test this hypothesis, the researchers collaborated with Robert J. D'Amato, MD, PhD, the Judah Folkman Chair in Surgery in the Vascular Biology Program at Boston Children's Hospital, and a professor of Ophthalmology at Harvard Medical School. Dr. D'Amato's team developed a mouse model with the THBS1 mutation and found that the mouse also had features of glaucoma.<br /><br /> "Thrombospondin-1 is well known as a potent inhibitor of blood vessel growth, or angiogenesis," said Dr. D'Amato, who has studied angiogenesis for more than three decades. "I assumed at first that THBS1 mutations were disrupting blood vessel formation in the eye, but our animal models showed normal angiogenesis. We realized that there must be another mechanism."<br /><br /> Specifically, D'Amato's lab showed that the mutation caused abnormal thrombospondin proteins to accumulate in the intraocular drainage structures of the eye involved with regulating IOP, which in turn, led to a buildup of pressure that damaged the optic nerve and led to the loss of retinal ganglion cells, thereby causing vision loss.<br /><br /> This was the first time that researchers identified this kind of disease mechanism for causing childhood glaucoma.<br /><br /> "This work highlights the power of international collaborations," said study co-author Owen M. Siggs MD, DPhil, associate professor at Flinders University and the Garvan Institute of Medical Research in Australia. "There's such incredible genetic diversity across the globe, and comparing this information is becoming more and more critical for discoveries like this."<br /><br /> Personalizing care for families with future study<br /><br /> The new study has significant clinical implications, according to the researchers. While more work remains before comprehensive genetic testing can be offered, every gene that is found presents another opportunity to be able to identify causative mutations in these families through screening, according to the authors.<br /><br /> Therapeutically, knowledge of this gene mutation can lead to earlier treatments with conventional therapies. For example, if a baby is born with this mutation, their eye care specialist can better inform the parents of the risks and develop an appropriate disease-monitoring and treatment plan.<br /><br /> Identifying this new mechanism and gene at the root of childhood glaucoma could also lead to new therapies that would target the accumulation of abnormal proteins. The researchers also aim to determine if other THBS1 mutations are involved in adult-onset disease, like primary open-angle glaucoma, or milder forms of the disease if the mutation is not as pronounced.<br /><br /> The researchers will also continue to look for new genes associated with childhood glaucoma in the hopes of one day developing very comprehensive screening.<br /><br /> "Dr. Wiggs is an international expert in glaucoma genetics and has worked tirelessly to unravel the genetic contributions to these blinding diseases. These findings provide important insights into the causes of childhood glaucoma and offer the prospect of targeted therapy," said Joan W. Miller, MD, Chair of Ophthalmology at Mass Eye and Ear and <keyword id="576044" type="General" weightage="50" keywordseo="massachusetts-general-hospital" source="Orion">Massachusetts General Hospital</keyword>, Ophthalmologist-in-Chief at Brigham and Women's Hospital, and Chair of Ophthalmology and the David Glendenning Cogan Professor of Ophthalmology at Harvard Medical School. "The collaboration is a powerful demonstration of the strength of bedside-to-bench-to-bedside translational research, in uncovering disease pathogenesis and developing therapies for patients."<br /><br /><b>SEE ALSO:</b><br /><br /> <b><a href="https://www.businessinsider.in/science/health/news/postpartum-depression-in-mothers-can-have-serious-consequences-on-the-childs-health-and-development/articleshow/95946346.cms">Postpartum depression in mothers can have serious consequences on the child’s health and development</a></b><br /><br /> <b><a href="https://www.businessinsider.in/stock-market/markets/news/foreign-investors-upgrade-india-as-dedicated-allocation-in-investment-portfolios-say-equity-experts/articleshow/95974087.cms">Foreign investors upgrade India as dedicated allocation in investment portfolios, say equity experts</a></b><br />

Researchers reveal new genetic mutation cause of childhood glaucoma

<ul class="summary-list"><li>After a short offseason, the <keyword id="6361805" type="UNKNOWN" weightage="60" keywordseo="NBA">NBA</keyword> is back, with training camps underway and preseason tipping off on Friday.</li><li>A flurry of activity has shaken up the standings.</li><li>The Lakers still top our power rankings as we head into the season.</li></ul><p>The longest season in NBA history led to the shortest offseason in history.</p><p>The NBA is back, just two months removed from the bubble. The compressed offseason led to a flurry of activity, with the draft and free agency being held over about one week.</p><p>The pecking order hasn't drastically changed, though some big names moved, and there are some teams on the rise and some on moving in the other direction.</p><p>With training camps underway and preseason tipping off on Friday, here's a look at our <keyword id="10412181" type="UNKNOWN" weightage="60" keywordseo="nba-power-rankings">NBA power rankings</keyword>.</p><p><em>* = lottery-pick rookie</em></p><h2><strong>30. Detroit Pistons</strong></h2><p><strong>2019-20 record:</strong> 20-46, 13th in East</p><p><strong>Biggest additions:</strong> Jerami Grant (F), Delon Wright (G), Mason Plumlee (C), Killian Hayes (G*)</p><p><strong>Biggest losses:</strong> Luke Kennard (G/F), Christian Wood (C)</p><p><strong>2020-21 outlook:</strong> The Pistons were active this offseason in re-shaping their roster, but it looks like just the beginning of a rebuild for a team with many questions at a lot of positions.</p><h2>29. Cleveland Cavaliers</h2><p><strong>2019-20 record:</strong> 19-46, 15th in East</p><p><strong>Biggest additions:</strong> Damyean Dotson (G/F), JaVale McGee (C), Isaac Okoro (G/F*)</p><p><strong>Biggest losses:</strong> Tristan Thompson (F/C)</p><p><strong>2020-21 outlook:</strong> The Cavs are in the midst of turning things over to the young core of Collin Sexton, Darius Garland, Kevin Porter Jr., and Isaac Okoro. Will a Kevin Love trade finally happen this season?</p><h2>28. New York Knicks</h2><p><strong>2019-20 record:</strong> 21-45, 12th in East</p><p><strong>Biggest additions:</strong> Austin Rivers (G), Nerlens Noel (C), Alec Burks (G/F), Obi Toppin (F*), Tom Thibodeau (coach)</p><p><strong>Biggest losses:</strong> Bobby Portis (F/C), Taj Gibson (C), Damyean Dotson (G/F)</p><p><strong>2020-21 outlook:</strong> The Knicks were patient and conservative this offseason, adding only cheap veterans to their young core. It's wise to continue a slow rebuild, but don't expect many more wins at MSG this season.</p><h2>27. Oklahoma City Thunder</h2><p><strong>2019-20 record:</strong> 44-28, 5th in West</p><p><strong>Biggest additions:</strong> Al Horford (F/C), George Hill (G), Trevor Ariza (F)</p><p><strong>Biggest losses:</strong> Chris Paul (G), Steven Adams (C), Dennis Schröder (G)</p><p><strong>2020-21 outlook:</strong> After wheeling-and-dealing through the offseason, the Thunder ultimately stripped away last year's surprising playoff roster for veterans and even more draft picks. OKC likely won't be an easy out, but it's hard to see them winning so many games again.</p><h2>26. Sacramento Kings</h2><p><strong>2019-20 record:</strong> 31-41, 11th in West</p><p><strong>Biggest additions:</strong> Hassan Whiteside (C), Frank Kaminsky (F/C), Tyrese Haliburton (G*)</p><p><strong>Biggest losses:</strong> Bogdan Bogdanovic (G/F)</p><p><strong>2020-21 outlook:</strong> The 2019-20 season was a letdown after the Kings narrowly missed the playoffs the year before. Sacramento wants to get back in the mix, and they'll need big seasons from De'Aaron Fox (who just signed a $163 million extension) and Marvin Bagley. </p><h2>25. Chicago Bulls</h2><p><strong>2019-20 record:</strong> 22-43, 11th in East</p><p><strong>Biggest additions:</strong> Patrick Williams (F*), Billy Donovan (coach)</p><p><strong>Biggest losses:</strong> Kris Dunn (G), Jim Boylen (coach)</p><p><strong>2020-21 outlook:</strong> The Bulls should improve with their coaching change. Though they have some nice talent at the top of their roster, their team's depth and core pieces are still in flux.</p><h2>24. Charlotte Hornets</h2><p><strong>2019-20 record:</strong> 23-42, 9th in East</p><p><strong>Biggest additions:</strong> Gordon Hayward (G/F), LaMelo Ball (G*)</p><p><strong>Biggest losses:</strong> Nic Batum (G/F)</p><p><strong><div type="image" title="gordon hayward" height="968" width="1290" msid="79667317" hostid="261"></div>2020-21 outlook:</strong> Drafting LaMelo Ball and signing Gordon Hayward to a $120 million deal gave the Hornets one of the more notable offseasons in the league. But Ball is a rookie PG joining a young, growing core, and Hayward isn't enough to lift the Hornets to another tier by himself.</p><h2>23. San Antonio Spurs</h2><p><strong>2019-20 record:</strong> 32-39, 10th in West</p><p><strong>Biggest additions:</strong> Devin Vassell (G/F*)</p><p><strong>Biggest losses:</strong> Bryn Forbes (G)</p><p><strong>2020-21 outlook:</strong> The Spurs are going through a slow rebuild, though they nearly made the playoffs last year, so it's not as if they're tanking. Development from young guards like Lonnie Walker or Dejounte Murray could push the Spurs up the standings.</p><h2>22. Orlando Magic</h2><p><strong>2019-20 record:</strong> 33-40, 8th in East</p><p><strong>Biggest additions:</strong> none</p><p><strong>Biggest losses:</strong> D.J. Augustin (G)</p><p><strong>2020-21 outlook</strong> The Magic have made the playoffs the last two years, but Augustin is quietly a big departure, versatile forward Jonathan Isaac will miss the season with a torn ACL, and the East has gotten better.</p><h2>21. Washington Wizards</h2><p><strong><div type="image" title="Houston Rockets Russell Westbrook Rokit phones" height="1182" width="1576" msid="79667322" hostid="261"></div>2019-20 record:</strong> 25-47, 10th in East</p><p><strong>Biggest additions:</strong> Russell Westbrook (G), Robin Lopez (C), Deni Avdija (F*)</p><p><strong>Biggest losses:</strong> John Wall (G)</p><p><strong>2020-21 outlook: </strong>The Wizards swapped Westbrook and Wall, giving Bradley Beal another back-court scoring partner (one not coming off a major injury). The Wizards should benefit from an infusion of talent, especially on the wing, with second-year forward Rui Hachimura and Deni Avdija, perhaps the steal of the draft.</p><h2>20. Memphis Grizzlies</h2><p><strong>2019-20 record:</strong> 34-39, 9th in West</p><p><strong>Biggest additions:</strong> Mario Hezonja (F)</p><p><strong>Biggest losses:</strong> Josh Jackson (G/F)</p><p><strong>2020-21 outlook:</strong> The surprise team of the 2019-20 season, the Grizzlies were on track to make the playoffs, though they benefited from an easy schedule before the league shut down. Perhaps we shouldn't write off Memphis again, but a step back from a young roster wouldn't be surprising, especially with Jaren Jackson Jr. recovering from a torn meniscus.</p><h2>19. Minnesota Timberwolves</h2><p><strong>2019-20 record:</strong> 19-45, 14th in West</p><p><strong>Biggest additions:</strong> Ricky Rubio (G), Ed Davis (F/C), Anthony Edwards (G/F*)</p><p><strong>Biggest losses:</strong> none</p><p><strong>2020-21 outlook:</strong> It's unclear how the trio of Rubio, No. 1 pick Edwards, and D'Angelo Russell will fit together, but the Wolves have gone all-in on chasing a playoff spot around Karl-Anthony Towns. This could be a fun, dynamic offensive team, but they may also be awful defensively and a bit choppy on offense with so many mouths to feed.</p><h2>18. Golden State Warriors</h2><p><strong>2019-20 record:</strong> 15-50, 15th in West</p><p><strong>Biggest additions:</strong> Kelly Oubre Jr. (G/F), Kent Bazemore (G/F), James Wiseman (C*)</p><p><strong>Biggest losses:</strong> none</p><p><strong>2020-21 outlook:</strong> Klay Thompson's torn Achilles is a devastating blow for a franchise looking to compete for a top-four seed once again. Stephen Curry is back and ready to re-reestablish himself as an elite player, but who else on this roster can be relied upon, from night to night?</p><h2>17. New Orleans Pelicans</h2><p><strong><div type="image" title="Zion Williamson" height="1750" width="2334" msid="79667327" hostid="261"></div>2019-20 record:</strong> 30-42, 13th in West</p><p><strong>Biggest additions:</strong> Steven Adams (C), Eric Bledsoe (G), Kira Lewis (G*)</p><p><strong>Biggest losses:</strong> Jrue Holiday (G), Derrick Favors (C), E'Twaun Moore (G)</p><p><strong>2020-21 outlook:</strong> The Pelicans were a winning team, by a healthy margin, in the 668 pre-bubble minutes Zion Williamson played last year. That's what they'll be counting on entering this season, as they surround the young core of Williamson, Brandon Ingram, and Lonzo Ball with capable veterans.</p><h2>16. Houston Rockets</h2><p><strong>2019-20 record:</strong> 44-28, 4th in West</p><p><strong>Biggest additions:</strong> John Wall (G), Christian Wood (C), Stephen Silas (coach)</p><p><strong>Biggest losses:</strong> Russell Westbrook (G), Robert Covington Jr. (F), Austin Rivers (G), Jeff Green (F), Mike D'Antoni (coach)</p><p><strong>2020-21 outlook: </strong>James Harden is a walking playoff appearance, and enough pieces are remaining in Houston to build a solid postseason contender. But will Harden's trade request erode team chemistry? Will the Rockets succumb and deal him to another team?</p><h2>15. Indiana Pacers</h2><p><strong>2019-20 record:</strong> 45-28, 4th in East</p><p><strong>Biggest additions:</strong> Nate Bjorkgren (coach)</p><p><strong>Biggest losses:</strong> Nate McMillan (coach)</p><p><strong>2020-21 outlook:</strong> The Pacers seem to be in flux. They've been a solid playoff team, albeit with a limited ceiling, but the futures of Victor Oladipo and Myles Turner seem to be in question.</p><h2>14. Atlanta Hawks</h2><p><strong><div type="image" title="trae young" height="999" width="1332" msid="79667331" hostid="261"></div>2019-20 record: </strong>20-47, 14th in East</p><p><strong>Biggest additions:</strong> Bogdan Bogdanovic (G/F), Danilo Gallinari (F), Rajon Rondo (G), Kris Dunn (G), Onyeka Okungwu (C*)</p><p><strong>Biggest losses:</strong> Jeff Teague (G)</p><p><strong>2020-21 outlook:</strong> The Hawks were the big spenders of the offseason. Some of the moves were questionable fits with their existing roster, but they are undoubtedly improved, and their offense should carry them to a playoff seed.</p><h2>13. Toronto Raptors</h2><p><strong>2019-20 record:</strong> 53-19, 2nd in East</p><p><strong>Biggest additions:</strong> Aron Baynes (C), Alex Len (C)</p><p><strong>Biggest losses:</strong> Marc Gasol (C), Serge Ibaka (F/C)</p><p><strong>2020-21 outlook:</strong> The Raptors retained Fred VanVleet to keep together the successful, talented core that includes Kyle Lowry, Pascal Siakam, and OG Anunoby. The bad <keyword id="6355005" type="UNKNOWN" weightage="60" keywordseo="news">news</keyword> is they lost Ibaka and Gasol, two fulcrums on both ends, in free agency, hurting the Raptors' seamless chemistry. Toronto is in the midst of a tricky re-tooling.</p><h2>12. Phoenix Suns</h2><p><strong>2019-20 record:</strong>34-39, 10th in West</p><p><strong>Biggest additions:</strong> Chris Paul (G), Jae Crowder (F), Jalen Smith (F*)</p><p><strong>Biggest losses:</strong> Ricky Rubio (G), Kelly Oubre (G/F), Frank Kaminsky (F)</p><p><strong>2020-21 outlook:</strong> After going 8-0 in the bubble and narrowly missing the playoffs, the Suns swung a trade for Chris Paul to boost their back-court. With Devin Booker entering his prime as an elite offensive player and development from two-way stud Mikal Bridges and center Deandre Ayton, the Suns should reach the playoffs.</p><h2>11. Dallas Mavericks</h2><p><strong>2019-20 record:</strong> 43-32, 7th in West</p><p><strong>Biggest additions:</strong> Josh Richardson (G/F), James Johnson (F)</p><p><strong>Biggest losses:</strong> Seth Curry (G)</p><p><strong>2020-21 outlook:</strong> Richardson is an excellent two-way addition to a team historically good on offense and poor on offense last season. Now the Mavs need their front-court of Kristaps Porzingis and Dwight Powell to get and stay healthy. In the meantime, Doncic is an early MVP favorite.</p><div type="image" title="luka doncic.JPG" height="660" width="1321" msid="79667338" hostid="261"></div><h2>10. Philadelphia 76ers</h2><p><strong>2019-20 record:</strong> 43-40, 6th in East</p><p><strong>Biggest additions:</strong> Danny Green (G/F), Seth Curry (G), Dwight Howard (C), Doc Rivers (coach)</p><p><strong>Biggest losses:</strong> Josh Richardson (G/F), Al Horford (F/C), Alec Burks (G/F)</p><p><strong>2020-21 outlook:</strong> New GM Daryl Morey immediately changed the Sixers' awkward construction and shipped out size for shooting. This roster makes more sense, and while Ben Simmons and Joel Embiid may continue to be an awkward fit, the pieces around them may make it a little less burdensome on offense.</p><h2>9. Utah Jazz</h2><p><strong>2019-20 record:</strong> 44-28, 6th in West</p><p><strong>Biggest additions:</strong> Derrick Favors (F/C)</p><p><strong>Biggest losses:</strong> Ed Davis (F/C)</p><p><strong>2020-21 outlook:</strong> The Jazz were one <a href="https://www.insider.com/video-jamal-murray-consoles-donovan-mitchell-nuggets-jazz-game-7-2020-9">in-and-out, last-second three-pointer in a Game 7</a> from advancing past the first round of the playoffs. They'll welcome back second-leading scorer Bojan Bogdanovic (who missed the bubble), and with a leap from Donovan Mitchell, they'll be right back in the playoff mix this year.</p><h2>8. Boston Celtics</h2><p><strong>2019-20 record:</strong> 48-24, 3rd in West</p><p><strong>Biggest additions:</strong> Tristan Thompson (F/C), Jeff Teague (G), Aaron Nesmith (G*)</p><p><strong>Biggest losses:</strong> Gordon Hayward (G/F), Enes Kanter (C), Brad Wanamaker (G)</p><p><strong>2020-21 outlook:</strong> The Celtics will miss Hayward, but his absence will open up more opportunities for Jayson Tatum and Jaylen Brown. Thompson adds some size and defense to one of the league's smallest teams. The big question is if Kemba Walker's knee will be healthy enough to be the second or third scorer the Celtics need to contend.</p><h2>7. Portland Trail Blazers</h2><p><strong><div type="image" title="damian lillard .JPG" height="870" width="1160" msid="79667344" hostid="261"></div>2019-20 record:</strong> 35-39, 9th in West</p><p><strong>Biggest additions:</strong> Robert Covington Jr. (F), Derrick Jones Jr. (F), Harry Giles (F/C), Enes Kanter (C)</p><p><strong>Biggest losses:</strong> Trevor Ariza (F)</p><p><strong>2020-21 outlook:</strong> Arguably, no team had a better, cleaner offseason than the Blazers, who strengthened their wing and bigs rotations around Damian Lillard and C.J. McCollum at a minimal cost. They made the Western Conference Finals in 2019; can they re-emerge as pseudo-contenders again?</p><h2>6. Brooklyn Nets</h2><p><strong>2019-20 record:</strong> 35-37, 7th in East</p><p><strong>Biggest additions:</strong> Landry Shamet (G), Jeff Green (F/C), Steve Nash (coach)</p><p><strong>Biggest losses:</strong> Garrett Temple (G), Wilson Chandler (F)</p><p><strong>2020-21 outlook:</strong> On paper, the Nets might boast the best roster in the league. Of course, they're relying on one star (Kevin Durant) coming back from an Achilles tear and another (Kyrie Irving) with a checkered injury history. We'll need to see they're healthy, but if they are, look out. Under first-time head coach Steve Nash, the Nets will be must-watch TV.</p><h2>5. Denver Nuggets</h2><p><strong>2019-20 record:</strong> 46-27, 3rd in West</p><p><strong>Biggest additions:</strong> JaMychal Green (F/C)</p><p><strong>Biggest losses:</strong> Jerami Grant (F), Mason Plumlee (C)</p><p><strong>2020-21 outlook:</strong> Denver's chemistry and grit wowed the NBA world as they fought to the Western Conference Finals last year. If Jamal Murray's star turn in the bubble and Michael Porter Jr.'s rapid development are real, Denver will be a contender this year.</p><h2>4. Miami Heat</h2><p><strong><div type="image" title="jimmy butler" height="843" width="1125" msid="79667350" hostid="261"></div>2019-20 record:</strong> 44-29, 5th in East</p><p><strong>Biggest additions:</strong> Avery Bradley (G), Maurice Harkless (F)</p><p><strong>Biggest losses:</strong> Jae Crowder (F), Derrick Jones Jr. (F)</p><p><strong>2020-21 outlook:</strong> Miami's impressive Finals run overshadowed a solid but unspectacular regular season. Not much has changed on the roster, though Bam Adebayo and Tyler Herro could make leaps this season. The Heat deserve respect as conference champions but don't expect them to run over the East as they did in the bubble.</p><h2>3. LA Clippers</h2><p><strong>2019-20 record:</strong> 49-23, 2nd in West</p><p><strong>Biggest additions:</strong> Serge Ibaka (F/C), Luke Kennard (F)</p><p><strong>Biggest losses:</strong> Montrezl Harrell (F/C), JaMychal Green (F/C), Landry Shamet (G), Doc Rivers (coach)</p><p><strong>2020-21 outlook:</strong> The Clippers' meltdown in the second round of the playoffs and reported <a href="https://www.insider.com/kawhi-leonard-paul-george-star-treatment-bothered-clippers-teammates-2020-12">chemistry issues</a> have overshadowed what looked like the scariest team in the league for much of the regular season. They still have Kawhi Leonard and Paul George and a deep, talented roster. If the locker-room issues sort themselves out, they can easily contend for a championship.</p><h2>2. <keyword id="578134" type="ORGANIZATION" weightage="60" keywordseo="Milwaukee-Bucks">Milwaukee Bucks</keyword></h2><p><strong>2019-20 record:</strong> 56-17, 1st in East</p><p><strong>Biggest additions:</strong> Jrue Holiday (G), Bobby Portis (F/C), D.J. Augustin (G)</p><p><strong>Biggest losses:</strong> Eric Bledsoe (G), George Hill (G), Welsey Matthews (F),  Robin Lopez (C)</p><p><strong>2020-21 outlook:</strong> Sure, the Bucks flamed out of the second round of the playoffs, botched a trade for Bogdan Bogdanovic, and still don't have Giannis Antetokounmpo's signature on the supermax contract extension. But they still have the reigning MVP and Defensive Player of the Year, a talented roster that upgraded by acquiring Holiday, and a proven effective system in the regular season. But this season is all about what happens in the playoffs.</p><div type="image" title="anthony davis lebron james" height="739" width="1479" msid="79667352" hostid="261"></div><h2>1. <keyword id="100883" type="ORGANIZATION" weightage="60" keywordseo="Los-Angeles-Lakers">Los Angeles Lakers</keyword></h2><p><strong>2019-20 record:</strong> 52-19, 1st in West</p><p><strong>Biggest additions:</strong> Montrezl Harrel (F/C), Marc Gasol (C), Dennis Schroeder (G), Wesley Matthews (F)</p><p><strong>Biggest losses:</strong> Danny Green (G/F), Dwight Howard (C), Avery Bradley (G), JaVale McGee (C)</p><p><strong>2020-21 outlook:</strong> The Lakers were the best team from start to finish last season, and they look poised to repeat this year. They upgraded the talent on their roster and got younger, crucial with a shortened offseason. LeBron James and Anthony Davis are locked in for the long-term, too. No other team has the same balance of talent and chemistry as the Lakers.</p>

NBA POWER RANKINGS: Where every team stands heading into the season

<p></p><div class="KonaFilter image-container display-table full"><div><div class="image on-image"></div><p></p></div></div>In the wildest turn of events of NBA free agency, <a href="http://www.businessinsider.com/clippers-deandre-jordan-last-minute-meeting-2015-7">the Los Angeles Clippers are trying to convince DeAndre Jordan to back out of his verbal deal with the Dallas Mavericks</a> at the 11th hour and return to Los Angeles.<p>It's borderline unprecedented and very much frowned upon to pressure a free agent change his mind once he has made a verbal agreement, but <a href="https://twitter.com/ramonashelburne/status/618841134203142144">Jordan reportedly told Doc Rivers</a> he has been having second thoughts, and here we are.</p><p>It's now all-out war between the two teams, with players from both teams tweeting out travel emojis indicting they're rushing to Houston, where Jordan is currently at his house.</p><p>Before Jordan can officially sign his five-year, $80 million contract with the Mavs at 12:01 a.m. eastern, the Clippers will meet with him. ESPN reports <a href="http://espn.go.com/nba/story/_/id/13221695/los-angeles-clippers-lobbying-deandre-jordan-back-deal-dallas-mavericks">that the Clippers are sending a full contingent to Houston, including Doc Rivers and owner Steve Ballmer</a>.</p><p><span style="line-height: 1.5em;">Not going down without a fight, Mavs owner Mark Cuban has travelled to Houston to join the fray:</span></p><div><div></div></div><p class="embed-spacer"></p><div><div></div></div><p class="embed-spacer"></p><p class="embed-spacer"><span style="line-height: 1.5em;">It appears that Chandler Parsons, who had dinner with Jordan six nights in a row before free agency opened, is rushing to Houston as well:</span><span style="line-height: 1.5em;">&#xa0;</span></p><div><div></div></div><p class="embed-spacer"></p><p class="embed-spacer"><span style="line-height: 1.5em;">After Parsons sent that tweet, Austin resident JJ Redick hopped in his emoji car.&#xa0;</span><span style="line-height: 1.5em;">Hereeeee comes JJ:</span></p><div><div></div></div><p><span style="line-height: 1.5em;">Woj can confirm:</span></p><div><div></div></div><p class="embed-spacer"><span style="line-height: 1.5em;">Blake Griffin is in:</span></p><div><div></div></div><p>Chris Paul, who reportedly contributed to Jordan's initial desire to leave L.A., was last seen on a banana boat in the Bahamas:</p><div><div></div></div><p class="embed-spacer">&#xa0;<span style="line-height: 1.5em;">He's coming too. He tweeted a banana boat emoji. I'm dead:</span></p><div><div></div></div><p class="embed-spacer"><span style="line-height: 1.5em;">This is the most absurd story of the year. </span><span style="line-height: 1.5em;">Let's see how it plays out!</span></p><div><div></div></div><p class="embed-spacer"></p>    <div class="margin-top">        <h3>NOW WATCH: <a href="http://www.businessinsider.com/1996-chicago-bulls-michael-jordan-where-are-they-now-2015-6">WHERE ARE THEY NOW? The historic 1996 Chicago Bulls championship team</a></h3>        <div>            <div>        <div class="ooyala-video-player" data-video-autoplay="false" data-video-id="VubjJ0dTqzvHoRlL_KGEDy0h1RAXeoXk" data-player-variable="ooyalapopvideo" id="ooyalaplayer_popvideo" style="width:1280px;height:720px"></div>        </div>        </div>            </div>

The Clippers and the Mavericks are going to war over DeAndre Jordan, and it's all hands on deck

<p><div class="KonaFilter image-container display-table"><div><div class="image"><p class="source"><span>Arnold Inuyaki / Flickr</span></p><p class="caption">Consistently a favorite of diners, The French Laundry in Yountville, California earned a spot on the list this year.</p></div><p></p></div></div>OpenTable just released their picks for the <a href="http://www.opentable.com/m/best-restaurants-in-america/">Best Restaurants in America for 2015</a>. </p><p>To compile the ranking, OpenTable pored over more than five million restaurant reviews submitted by verified OpenTable diners for 20,000 restaurants, covering all 50 states and Washington DC.</p><p>St. Francis Winery &amp; Vineyards in Santa Rosa, California, earned the No. 1 spot, with Mama's Fish House in Paia, Hawaii, and Kai at the Sheraton Wild Horse Pass Resort in Chandler, Arizona, rounding out the top three.</p><p><strong>Here's the full list of the 100 best restaurants in America:</strong></p><p><a href="http://www.opentable.com/acquerello">Acquerello</a> - San Francisco, California</p><p><a href="http://www.opentable.com/addison-restaurant">Addison Restaurant</a> - San Diego, California</p><p><a href="http://www.opentable.com/ambience-los-altos">Ambience</a> - Los Altos, California</p><p><a href="http://www.opentable.com/arethusa-al-tavolo">Arethusa al Tavolo</a> - Bantam, Connecticut</p><p><a href="http://www.opentable.com/arroyo-vino">Arroyo Vino</a> - Santa Fe, New Mexico</p><p><a href="http://www.opentable.com/artisanal-restaurant">Artistanal Restaurant</a> - Banner Elk, North Carolina</p><p><a href="http://www.opentable.com/atera">Atera</a> - New York, New York</p><p><a href="http://www.opentable.com/auberge-du-soleil">Auberge du Soleil</a> - Rutherford, California</p><p><div class="KonaFilter image-container display-table"><div><div class="image"><p class="source"><span>Bacchanalia</span></p><p class="caption">Bacchanalia in Atlanta, Georgia.</p></div><p></p></div></div><a href="http://www.opentable.com/bacchanalia">Bacchanalia</a> - Atlanta, Georgia</p><p><a href="http://www.opentable.com/barmini-by-jose-andres">barmini by by José Andrés</a> - Washington, D.C.</p><p><a href="http://www.opentable.com/bavettes">Bavettes</a> - Chicago, Illinois</p><p><a href="http://www.opentable.com/benu">Benu</a> - San Francisco, California</p><p><a href="http://www.opentable.com/blue-hill-at-stone-barns">Blue Hill at Stone Barns</a> - Pocantico Hills, New York</p><p><a href="http://www.opentable.com/boka">Boka</a> - Chicago, Illinois</p><p><a href="http://www.opentable.com/bones-atlanta">Bones</a> - Atlanta, Georgia</p><p><a href="http://www.opentable.com/bouchard-restaurant-and-inn">Bouchard Restaurant and Inn</a> - Newport, Rhode Island</p><p><div class="KonaFilter image-container display-table"><div><div class="image"><p class="source"><span>Yelp/Wing Y.</span></p><p class="caption">Tomato confit at Bouley in New York City.</p></div><p></p></div></div><a href="http://www.opentable.com/bouley">Bouley</a> - New York, New York</p><p><a href="http://www.opentable.com/cafe-juanita">Café Juanita</a> - Kirkland, Washington</p><p><a href="http://www.opentable.com/cafe-monarch">Café Monarch</a> - Scottsdale, Arizona</p><p><a href="http://www.opentable.com/cafe-provence">Café Provence</a> - Prairie Villa, Kansas</p><p><a href="http://www.opentable.com/the-capital-grille-chicago-lombard">The Capital Grille</a> - Lombard, Illinois</p><p><a href="http://www.opentable.com/the-capital-grille-minneapolis">The Capital Grille</a> - Minneapolis, Minnesota</p><p><a href="http://www.opentable.com/carlos-bistro">Carlos' Bistro</a> - Colorado Springs, Colorado</p><p><a href="http://www.opentable.com/castagna-restaurant">Castagna Restaurant</a> - Portland, Oregon</p><p><a href="http://www.opentable.com/the-cellars">The Cellars</a> - Virginia Beach, Virginia</p><p><div class="KonaFilter image-container display-table"><div><div class="image on-image"><p class="source"><span>Anthony N/Yelp</span></p><p class="caption">Charleston in Baltimore, Maryland.</p></div><p></p></div></div><a href="http://www.opentable.com/charleston">Charleston</a> - Baltimore, Maryland</p><p><a href="http://www.opentable.com/chez-francois-vermilion">Chez Francois</a> - Vermillion, Ohio</p><p><a href="http://www.opentable.com/chez-nous-french-restaurant">Chez Nous French Restaurant</a> - Humble, Texas</p><p><a href="http://www.opentable.com/chimney-park">Chimney Park</a> - Windsor, Colorado</p><p><a href="http://www.opentable.com/circle-brunch-the-breakers">Circle Brunch-The Breakers</a> - Palm Beach, Florida</p><p><a href="http://www.opentable.com/clementines">Clementines</a> - Avon-By-The-Sea, New Jersey</p><p><a href="http://www.opentable.com/collage-restaurant">Collage Restaurant</a> - St. Augustine, Florida</p><p><a href="http://www.opentable.com/daniel">Daniel</a> - New York, New York</p><p><a href="http://www.opentable.com/daniel-lounge-seating">Daniel-Lounge Seating</a> - New York, New York</p><p><a href="http://www.opentable.com/del-posto">Del Posto</a> - New York, New York</p><p><a href="http://www.opentable.com/eleven-madison-park">Eleven Madison Park</a> - New York, New York</p><p><a href="http://www.opentable.com/farmhouse-inn-and-restaurant">Farmhouse Inn &amp; Restaurant</a> - Forestville, California</p><p><a href="http://www.opentable.com/fearrington-house-restaurant">Fearrington House Restaurant</a> - Pittsboro, North Carolina</p><p><a href="http://www.opentable.com/forage">Forage</a> - Salt Lake City, Utah</p><p><div class="KonaFilter image-container display-table"><div><div class="image"><p class="source"><span>Flickr/arndog</span></p><p class="caption">Dessert from The French Laundry in Yountville, California.</p></div><p></p></div></div><a href="http://www.opentable.com/the-french-laundry">The French Laundry</a> - Yountville, California</p><p><a href="http://www.opentable.com/the-french-room">The French Room</a> - Dallas Texas</p><p><a href="http://www.opentable.com/geronimo-santa-fe">Geronimo</a> - Santa Fe, New Mexico</p><p><a href="http://www.opentable.com/gramercy-tavern">Gramercy Tavern</a> - New York, New York</p><p><a href="http://www.opentable.com/goodstone-inn-and-estate-restaurant">The Goodstone Inn &amp; Estate Restaurant</a> - Middleburg, Virginia</p><p><a href="http://www.opentable.com/halls-chophouse">Halls Chophouse</a> - Charleston, South Carolina</p><p><a href="http://www.opentable.com/hannas-prime-steak">Hannas Prime Steak</a> - Rancho Santa Margarita, California</p><p><a href="http://www.opentable.com/jillians">Jillian's</a> - Palm Desert, California</p><p><a href="http://www.opentable.com/joans-in-the-park">Joan's in the Park</a> - Saint Paul, Minnesota</p><p><a href="http://www.opentable.com/joseph-tambellini">Joseph Tambellini</a> - Pittsburgh, Pennsylvania</p><p><div class="KonaFilter image-container display-table"><div><div class="image on-image"><p class="source"><span>Wild Horse Pass Resort</span></p><p class="caption">Kai at the Sheraton Wild Horse Pass Resort in Chandler, Arizona.</p></div><p></p></div></div><a href="http://www.opentable.com/kai-sheraton-wild-horse-pass-resort">Kai - Sheraton Wild Horse Pass Resort</a> - Chandler, Arizona</p><p><a href="http://www.opentable.com/king-umberto-restaurant">King Umberto Restaurant</a> - Elmont, New York</p><p><a href="http://www.opentable.com/kusakabe">KUSAKABE</a> - San Francisco, California</p><p><a href="http://www.opentable.com/lauberge-chez-francois">L'Auberge Chez François</a> - Great Falls, Virginia</p><p><a href="http://www.opentable.com/la-folie">La Folie</a> - San Francisco, California</p><p><a href="http://www.opentable.com/la-grenouille">La Grenouille</a> - New York, New York</p><p><a href="http://www.opentable.com/la-mer-at-halekulani">La Mer at Halekulani</a> - Honolulu, Hawaii</p><p><a href="http://www.opentable.com/laurel">Laurel</a> - Philadelphia, Pennsylvania</p><p><div class="KonaFilter image-container display-table"><div><div class="image"><p class="source"><span>Shimon &amp; Tammar</span></p><p class="caption">Le Bernardin in New York City.</p></div><p></p></div></div><a href="http://www.opentable.com/le-bernardin">Le Bernardin</a> - New York, New York</p><p><a href="http://www.opentable.com/le-cep">Le Cep</a> - Fort Worth, Texas</p><p><a href="http://www.opentable.com/les-nomades">Les Nomades</a> - Chicago, Illinois</p><p><a href="http://www.opentable.com/mamas-fish-house">Mama's Fish House</a> - Paia, Hawaii</p><p><a href="http://www.opentable.com/marche-moderne">Marché Moderne</a> - Costa Mesa, California</p><p><a href="http://www.opentable.com/mcninch-house">McNinch House</a> - Charlotte, North Carolina</p><p><a href="http://www.opentable.com/michaels-south-point-casino">Michael's-South Point Casino</a> - Las Vegas, Nevada</p><p><a href="http://www.opentable.com/mistral-sherman-oaks">Mistral</a> - Sherman Oaks, California</p><p><a href="http://www.opentable.com/the-modern-dining-room">The Modern-Dining Room</a> - New York, New York</p><p><a href="http://www.opentable.com/montalcino-ristorante-italiano">Montalcino Ristorante Italiano</a> - Issaquah, Washington</p><p><div class="KonaFilter image-container display-table"><div><div class="image"><p class="source"><span>Ed M./Yelp</span></p><p class="caption">Halibut at n/naka in Los Angeles.</p></div><p></p></div></div><a href="http://www.opentable.com/n-naka">n/naka</a> - Los Angeles, California</p><p><a href="http://www.opentable.com/nicholas">Nicholas</a> - Red Bank, New Jersey</p><p><a href="http://www.opentable.com/normans-at-the-ritz-carlton-orlando">Norman's at the Ritz-Carlton</a> - Orlando, Florida</p><p><a href="http://www.opentable.com/o-ya-restaurant">o ya</a> - Boston, Massachusetts</p><p><a href="http://www.opentable.com/orchids-at-palm-court-hilton-cincinnati-netherland-plaza">Orchids at Palm Court</a> - Cincinnati, Ohio</p><p><a href="http://www.opentable.com/per-se">Per Se</a> - New York, New York</p><p><a href="http://www.opentable.com/afternoon-tea-the-phoenician">The Phoenician-Afternoon Tea</a> - Scottsdale, Arizona</p><p><a href="http://www.opentable.com/quince-restaurant-san-francisco">Quince Restaurant</a> - San Francisco, California</p><p><div class="KonaFilter image-container display-table"><div><div class="image"><p class="source"><span>Chef John Besh/Facebook</span></p><p class="caption">Restaurant August in New Orleans, Louisiana.</p></div><p></p></div></div><a href="http://www.opentable.com/restaurant-august">Restaurant August</a> - New Orleans, Louisiana</p><p><a href="http://www.opentable.com/restaurant-lorenas">Restaurant Lorena's</a> - Maplewood, New Jersey</p><p><a href="http://www.opentable.com/roe">Roe</a> - Portland, Oregon</p><p><a href="http://www.opentable.com/rudy-and-paco-restaurant-and-bar">Rudy &amp; Paco Restaurant &amp; Bar</a> - Galveston, Texas</p><p><a href="http://www.opentable.com/ruths-chris-steak-house-baton-rouge">Ruth's Chris Steak House</a> - Baton Rouge, Louisiana</p><p><a href="http://www.opentable.com/second-empire-restaurant-and-tavern">Second Empire Restaurant and Tavern</a> - Raleigh, North Carolina</p><p><a href="http://www.opentable.com/sette-bernardsville">Sette</a> - Bernardsville, New Jersey</p><p><a href="http://www.opentable.com/shinbay">ShinBay</a> - Scottsdale, Arizona</p><p><a href="http://www.opentable.com/ski-tip-lodge-restaurant">Ski Tip Lodge</a> - Keystone, Colorado</p><p><a href="http://www.opentable.com/sonoma">Sonoma</a> - Princeton, Massachusetts</p><p><div class="KonaFilter image-container display-table"><div><div class="image"><p class="source"><span>Jennifer P/Yelp</span></p><p class="caption">St. Francis Winery &amp; Vineyards in Santa Rosa, California is the No. 1 restaurant in America this year.</p></div><p></p></div></div><a href="http://www.opentable.com/st-francis-winery-and-vineyards">St. Francis Winery &amp; Vineyards</a> - Santa Rosa, California</p><p><a href="http://www.opentable.com/state-and-lemp">State &amp; Lemp</a> - Boise, Idaho</p><p><a href="http://www.opentable.com/sushi-nakazawa-sushi-bar">Sushi Nakazawa-Sushi Bar</a> - New York, New York</p><p><a href="http://www.opentable.com/talulas-garden">Talula's Garden</a> - Philadelphia, Pennsylvania</p><p><a href="http://www.opentable.com/thomas-henkelmann-homestead-inn">Thomas Henkelmann-Homestead Inn</a> - Greenwich, Connecticut</p><p><a href="http://www.opentable.com/trattoria-lincontro">Trattoria L'incontro</a> - Astoria, New York</p><p><a href="http://www.opentable.com/trulucks-seafood-steak-and-crab-house-austin-downtown">Truluck's Seafood, Steak and Crab House</a> - Austin, Texas</p><p><div class="KonaFilter image-container display-table"><div><div class="image"><p class="source"><span>Umami/Yelp</span></p><p class="caption">Umami in Chagrin Falls, Ohio.</p></div><p></p></div></div><a href="http://www.opentable.com/umami-chagrin-falls">Umami</a> - Chagrin Falls, Ohio</p><p><a href="http://www.opentable.com/vedge">Vedge</a> - Philadelphia, Pennsylvania</p><p><a href="http://www.opentable.com/vernick-food-and-drink">Vernick Food &amp; Drink</a> - Philadelphia, Pennsylvania</p><p><a href="http://www.opentable.com/vetri">Vetri</a> - Philadelphia, Pennsylvania</p><p><a href="http://www.opentable.com/volver">Volver</a> - Philadelphia, Pennsylvania</p><p><a href="http://www.opentable.com/waypoint-seafood-and-grill">Waypoint Seafood &amp; Grill</a> - Williamsburg, Virginia</p><p><a href="http://www.opentable.com/yonos-restaurant">Yono's Restaurant</a> - Albany, New York</p><p><a href="http://www.opentable.com/zahav">Zahav</a> - Philadelphia, Pennsylvania</p>

The 100 best restaurants in America, according to OpenTable

How the DeAndre Jordan fiasco - the most absurd 12 hours in free agency history - genuinely changed the NBA

<p></p><div class="KonaFilter image-container display-table"><div><div class="image on-image"></div><p></p></div></div>Everyone wants to save money.<p>However, it's easier for some people than for others.</p><p>The ability to save doesn't just depend on your income - it's your income versus your costs that really matters. And in some US cities, the cost of living is much more manageable than in others.</p><p><a href="http://www.debt.com/tools-tips/worst-cities-for-saving-map">Debt.com</a> looked at 2015 gas prices from GasBuddy and home and rent data from Zillow, as well as late 2014 unemployment rates from the Bureau of Labor Statistics and 2013 median income and population data from the Census Bureau to determine in which US cities it's easiest for residents to save - or not to save - money.</p><p>In map form, it's pretty clear that &#xa0;the worst cities for setting aside savings tend to be concentrated in the Northeast and on the West Coast, while there are a handful of best cities clustered in the Midwest. Scroll over a dot to see the city and its rank. Click the dot for more details on the cost of living in that area. (Note: You may have to zoom out once to see the most affordable city!)</p><p>Mobile readers might prefer to visit <a href="http://www.debt.com/tools-tips/worst-cities-for-saving-map">Debt.com</a> to use the interactive map.</p><div><div></div></div><p class="embed-spacer">And here's the ranking in list form, No. 1 being the easiest city to save money:</p><div><div><table class="tg"><tr><th class="tg-hgcj">City</th>    <th class="tg-hgcj">State</th>    <th class="tg-hgcj">Rank</th>    <th class="tg-e3zv"></th>    <th class="tg-e3zv"></th>    <th class="tg-e3zv"></th>    <th class="tg-hgcj">City</th>    <th class="tg-hgcj">State</th>    <th class="tg-hgcj">Rank</th>    <th class="tg-031e"></th>    <th class="tg-031e"></th>    <th class="tg-031e"></th>  </tr><tr><td class="tg-7sui">Anchorage</td>    <td class="tg-vn4c">Alaska</td>    <td class="tg-lf39">1</td>    <td class="tg-7sui">Cincinnati</td>    <td class="tg-vn4c">Ohio</td>    <td class="tg-lf39">26</td>    <td class="tg-7sui">Honolulu</td>    <td class="tg-vn4c">Hawaii</td>    <td class="tg-lf39">51</td>    <td class="tg-7sui">New Orleans</td>    <td class="tg-vn4c">La.</td>    <td class="tg-lf39">76</td>  </tr><tr><td class="tg-34fq">Portland</td>    <td class="tg-031e">Ore.</td>    <td class="tg-c9cr">2</td>    <td class="tg-34fq">Tulsa</td>    <td class="tg-031e">Okla.</td>    <td class="tg-c9cr">27</td>    <td class="tg-34fq">Scottsdale</td>    <td class="tg-031e">Ariz.</td>    <td class="tg-c9cr">52</td>    <td class="tg-34fq">Newark</td>    <td class="tg-031e">N.J.</td>    <td class="tg-c9cr">77</td>  </tr><tr><td class="tg-7sui">Boise</td>    <td class="tg-vn4c">Idaho</td>    <td class="tg-lf39">3</td>    <td class="tg-7sui">Irving</td>    <td class="tg-vn4c">Texas</td>    <td class="tg-lf39">28</td>    <td class="tg-7sui">Denver</td>    <td class="tg-vn4c">Colo.</td>    <td class="tg-lf39">53</td>    <td class="tg-7sui">Boston</td>    <td class="tg-vn4c">Mass.</td>    <td class="tg-lf39">78</td>  </tr><tr><td class="tg-34fq">Madison</td>    <td class="tg-031e">Wis.</td>    <td class="tg-c9cr">4</td>    <td class="tg-34fq">Charlotte</td>    <td class="tg-031e">N.C.</td>    <td class="tg-c9cr">29</td>    <td class="tg-34fq">Tucson</td>    <td class="tg-031e">Ariz.</td>    <td class="tg-c9cr">54</td>    <td class="tg-34fq">Hialeah</td>    <td class="tg-031e">Fla.</td>    <td class="tg-c9cr">79</td>  </tr><tr><td class="tg-7sui">Lincoln</td>    <td class="tg-vn4c">Neb.</td>    <td class="tg-lf39">5</td>    <td class="tg-7sui">Albuquerque</td>    <td class="tg-vn4c">N.M.</td>    <td class="tg-lf39">30</td>    <td class="tg-7sui">Baltimore</td>    <td class="tg-vn4c">Md.</td>    <td class="tg-lf39">55</td>    <td class="tg-7sui">Washington</td>    <td class="tg-vn4c">D.C.</td>    <td class="tg-lf39">80</td>  </tr><tr><td class="tg-34fq">Lexington</td>    <td class="tg-031e">Ky.</td>    <td class="tg-c9cr">6</td>    <td class="tg-34fq">Orlando</td>    <td class="tg-031e">Fla.</td>    <td class="tg-c9cr">31</td>    <td class="tg-34fq">Glendale</td>    <td class="tg-031e">Ariz.</td>    <td class="tg-c9cr">56</td>    <td class="tg-34fq">Sacramento</td>    <td class="tg-031e">Calif.</td>    <td class="tg-c9cr">81</td>  </tr><tr><td class="tg-7sui">Chesapeake</td>    <td class="tg-vn4c">Va.</td>    <td class="tg-lf39">7</td>    <td class="tg-7sui">Aurora</td>    <td class="tg-vn4c">Colo.</td>    <td class="tg-lf39">32</td>    <td class="tg-7sui">Henderson</td>    <td class="tg-vn4c">Nev.</td>    <td class="tg-lf39">57</td>    <td class="tg-7sui">Seattle</td>    <td class="tg-vn4c">Wash.</td>    <td class="tg-lf39">82</td>  </tr><tr><td class="tg-34fq">Louisville</td>    <td class="tg-031e">Ky.</td>    <td class="tg-c9cr">8</td>    <td class="tg-34fq">Norfolk</td>    <td class="tg-031e">Va.</td>    <td class="tg-c9cr">33</td>    <td class="tg-34fq">Dallas</td>    <td class="tg-031e">Texas</td>    <td class="tg-c9cr">58</td>    <td class="tg-34fq">Fremont</td>    <td class="tg-031e">Calif.</td>    <td class="tg-c9cr">83</td>  </tr><tr><td class="tg-7sui">Virginia Beach</td>    <td class="tg-vn4c">Va.</td>    <td class="tg-lf39">9</td>    <td class="tg-7sui">Wichita</td>    <td class="tg-vn4c">Kansas</td>    <td class="tg-lf39">34</td>    <td class="tg-7sui">Nashville</td>    <td class="tg-vn4c">Tenn.</td>    <td class="tg-lf39">59</td>    <td class="tg-7sui">Riverside</td>    <td class="tg-vn4c">Calif.</td>    <td class="tg-lf39">84</td>  </tr><tr><td class="tg-34fq">Omaha</td>    <td class="tg-031e">Neb.</td>    <td class="tg-c9cr">10</td>    <td class="tg-34fq">Oklahoma City</td>    <td class="tg-031e">Okla.</td>    <td class="tg-c9cr">35</td>    <td class="tg-34fq">Austin</td>    <td class="tg-031e">Texas</td>    <td class="tg-c9cr">60</td>    <td class="tg-34fq">Miami</td>    <td class="tg-031e">Fla.</td>    <td class="tg-c9cr">85</td>  </tr><tr><td class="tg-7sui">Gilbert</td>    <td class="tg-vn4c">Ariz.</td>    <td class="tg-lf39">11</td>    <td class="tg-7sui">St. Paul</td>    <td class="tg-vn4c">Minn.</td>    <td class="tg-lf39">36</td>    <td class="tg-7sui">Jersey City</td>    <td class="tg-vn4c">N.J.</td>    <td class="tg-lf39">61</td>    <td class="tg-7sui">Chula Vista</td>    <td class="tg-vn4c">Calif.</td>    <td class="tg-lf39">86</td>  </tr><tr><td class="tg-34fq">Richmond</td>    <td class="tg-031e">Va.</td>    <td class="tg-c9cr">12</td>    <td class="tg-34fq">St. Petersburg</td>    <td class="tg-031e">Fla.</td>    <td class="tg-c9cr">37</td>    <td class="tg-34fq">Buffalo</td>    <td class="tg-031e">N.Y.</td>    <td class="tg-c9cr">62</td>    <td class="tg-34fq">Chicago</td>    <td class="tg-031e">Illinois</td>    <td class="tg-c9cr">87</td>  </tr><tr><td class="tg-7sui">Raleigh</td>    <td class="tg-vn4c">N.C.</td>    <td class="tg-lf39">13</td>    <td class="tg-7sui">Colorado Springs</td>    <td class="tg-vn4c">Colo.</td>    <td class="tg-lf39">38</td>    <td class="tg-7sui">Cleveland</td>    <td class="tg-vn4c">Ohio</td>    <td class="tg-lf39">63</td>    <td class="tg-7sui">Irvine</td>    <td class="tg-vn4c">Calif.</td>    <td class="tg-lf39">88</td>  </tr><tr><td class="tg-34fq">Fort Wayne</td>    <td class="tg-031e">Ind.</td>    <td class="tg-c9cr">14</td>    <td class="tg-34fq">Jacksonville</td>    <td class="tg-031e">Fla.</td>    <td class="tg-c9cr">39</td>    <td class="tg-34fq">St. Louis</td>    <td class="tg-031e">Mo.</td>    <td class="tg-c9cr">64</td>    <td class="tg-34fq">Fresno</td>    <td class="tg-031e">Calif.</td>    <td class="tg-c9cr">89</td>  </tr><tr><td class="tg-7sui">Plano</td>    <td class="tg-vn4c">Texas</td>    <td class="tg-lf39">15</td>    <td class="tg-7sui">Fort Worth</td>    <td class="tg-vn4c">Texas</td>    <td class="tg-lf39">40</td>    <td class="tg-7sui">Phoenix</td>    <td class="tg-vn4c">Ariz.</td>    <td class="tg-lf39">65</td>    <td class="tg-7sui">San Bernardino</td>    <td class="tg-vn4c">Calif.</td>    <td class="tg-lf39">90</td>  </tr><tr><td class="tg-34fq">Winston-Salem</td>    <td class="tg-031e">N.C.</td>    <td class="tg-c9cr">16</td>    <td class="tg-34fq">Minneapolis</td>    <td class="tg-031e">Minn.</td>    <td class="tg-c9cr">41</td>    <td class="tg-34fq">North Las Vegas</td>    <td class="tg-031e">Nev.</td>    <td class="tg-c9cr">66</td>    <td class="tg-34fq">San Diego</td>    <td class="tg-031e">Calif.</td>    <td class="tg-c9cr">91</td>  </tr><tr><td class="tg-7sui">Greensboro</td>    <td class="tg-vn4c">N.C.</td>    <td class="tg-lf39">17</td>    <td class="tg-7sui">Corpus Christi</td>    <td class="tg-vn4c">Texas</td>    <td class="tg-lf39">42</td>    <td class="tg-7sui">Las Vegas</td>    <td class="tg-vn4c">Nev.</td>    <td class="tg-lf39">67</td>    <td class="tg-7sui">Anaheim</td>    <td class="tg-vn4c">Calif.</td>    <td class="tg-lf39">92</td>  </tr><tr><td class="tg-34fq">Toledo</td>    <td class="tg-031e">Ohio</td>    <td class="tg-c9cr">18</td>    <td class="tg-34fq">Milwaukee</td>    <td class="tg-031e">Wis.</td>    <td class="tg-c9cr">43</td>    <td class="tg-34fq">Baton Rouge</td>    <td class="tg-031e">La.</td>    <td class="tg-c9cr">68</td>    <td class="tg-34fq">Santa Ana</td>    <td class="tg-031e">Calif.</td>    <td class="tg-c9cr">93</td>  </tr><tr><td class="tg-7sui">Lubbock</td>    <td class="tg-vn4c">Texas</td>    <td class="tg-lf39">19</td>    <td class="tg-7sui">Indianapolis</td>    <td class="tg-vn4c">Ind.</td>    <td class="tg-lf39">44</td>    <td class="tg-7sui">Reno</td>    <td class="tg-vn4c">Nev.</td>    <td class="tg-lf39">69</td>    <td class="tg-7sui">Stockton</td>    <td class="tg-vn4c">Calif.</td>    <td class="tg-lf39">94</td>  </tr><tr><td class="tg-34fq">Columbus</td>    <td class="tg-031e">Ohio</td>    <td class="tg-c9cr">20</td>    <td class="tg-34fq">Laredo</td>    <td class="tg-031e">Texas</td>    <td class="tg-c9cr">45</td>    <td class="tg-34fq">Bakersfield</td>    <td class="tg-031e">Calif.</td>    <td class="tg-c9cr">70</td>    <td class="tg-34fq">San Jose</td>    <td class="tg-031e">Calif.</td>    <td class="tg-c9cr">95</td>  </tr><tr><td class="tg-7sui">Chandler</td>    <td class="tg-vn4c">Ariz.</td>    <td class="tg-lf39">21</td>    <td class="tg-7sui">Kansas City</td>    <td class="tg-vn4c">Mo.</td>    <td class="tg-lf39">46</td>    <td class="tg-7sui">Houston</td>    <td class="tg-vn4c">Texas</td>    <td class="tg-lf39">71</td>    <td class="tg-7sui">Oakland</td>    <td class="tg-vn4c">Calif.</td>    <td class="tg-lf39">96</td>  </tr><tr><td class="tg-34fq">Pittsburgh</td>    <td class="tg-031e">Pa.</td>    <td class="tg-c9cr">22</td>    <td class="tg-34fq">El Paso</td>    <td class="tg-031e">Texas</td>    <td class="tg-c9cr">47</td>    <td class="tg-34fq">Detroit</td>    <td class="tg-031e">Mich.</td>    <td class="tg-c9cr">72</td>    <td class="tg-34fq">Long Beach</td>    <td class="tg-031e">Calif.</td>    <td class="tg-c9cr">97</td>  </tr><tr><td class="tg-7sui">Durham</td>    <td class="tg-vn4c">N.C.</td>    <td class="tg-lf39">23</td>    <td class="tg-7sui">San Antonio</td>    <td class="tg-vn4c">Texas</td>    <td class="tg-lf39">48</td>    <td class="tg-7sui">Philadelphia</td>    <td class="tg-vn4c">Pa.</td>    <td class="tg-lf39">73</td>    <td class="tg-7sui">San Francisco</td>    <td class="tg-vn4c">Calif.</td>    <td class="tg-lf39">98</td>  </tr><tr><td class="tg-34fq">Garland</td>    <td class="tg-031e">Texas</td>    <td class="tg-c9cr">24</td>    <td class="tg-34fq">Tampa</td>    <td class="tg-031e">Fla.</td>    <td class="tg-c9cr">49</td>    <td class="tg-34fq">Atlanta</td>    <td class="tg-031e">Ga.</td>    <td class="tg-c9cr">74</td>    <td class="tg-34fq">New York</td>    <td class="tg-031e">N.Y.</td>    <td class="tg-c9cr">99</td>  </tr><tr><td class="tg-7sui">Arlington</td>    <td class="tg-vn4c">Texas</td>    <td class="tg-lf39">25</td>    <td class="tg-7sui">Mesa</td>    <td 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