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New Delhi, A new type of "<keyword id="18985759" type="General" weightage="20" keywordseo="inverse-vaccine" source="Orion">inverse vaccine</keyword>" has been shown in the lab setting to completely reverse autoimmune diseases like <keyword id="23087" type="General" weightage="20" keywordseo="multiple-sclerosis" source="Orion">multiple sclerosis</keyword> and type 1 <keyword id="6359018" type="General" weightage="20" keywordseo="diabetes" source="Orion">diabetes</keyword>, all without shutting down the rest of the immune system, according to a study. A typical <keyword id="24209" type="General" weightage="20" keywordseo="vaccine" source="Orion">vaccine</keyword> teaches the human immune system to recognise a virus or bacteria as an enemy that should be attacked. However, the new vaccine developed by researchers at the University of Chicago's Pritzker School of Molecular Engineering (PME) in the US does just the opposite: it removes the immune system's memory of one molecule. While such immune memory erasure would be unwanted for infectious diseases, it can stop autoimmune reactions like those seen in multiple sclerosis, type I diabetes, or rheumatoid arthritis, in which the immune system attacks a person's healthy tissues, the researchers said. The vaccine, described in the journal Nature Biomedical Engineering, takes advantage of how the liver naturally marks molecules from broken-down cells with "do not attack" flags to prevent autoimmune reactions to cells that die by natural processes. The team coupled an antigen-a molecule being attacked by the immune system-with a molecule resembling a fragment of an aged cell that the liver would recognise as friend, rather than an enemy. The team showed how the vaccine could successfully stop the autoimmune reaction associated with a multiple-sclerosis-like disease. "In the past, we showed that we could use this approach to prevent autoimmunity," said <keyword id="18985758" type="General" weightage="50" keywordseo="jeffrey-hubbell" source="Orion">Jeffrey Hubbell</keyword>, the Eugene Bell Professor in Tissue Engineering and lead author of the new paper. "But what is so exciting about this work is that we have shown that we can treat diseases like multiple sclerosis after there is already ongoing inflammation, which is more useful in a real-world context," Hubbell said. Today, autoimmune diseases are generally treated with drugs that broadly shut down the immune system. "These treatments can be very effective, but you're also blocking the immune responses necessary to fight off infections and so there are a lot of side effects," said Hubbell. "If we could treat patients with an inverse vaccine instead, it could be much more specific and lead to fewer side effects," he added. Initial phase I safety trials of a antigen therapy based on this preclinical work have already been carried out in people with celiac disease, an autoimmune disease that is associated with eating wheat, barley and rye, and phase I safety trials are under way in multiple sclerosis, the researchers said. Those trials are conducted by Swiss pharmaceutical company Anokion SA, which helped fund the new work and which Hubbell cofounded and is a consultant, board member, and equity holder. "There are no clinically approved inverse vaccines yet, but we are incredibly excited about moving this technology forward," Hubbell added.

New 'inverse vaccine' shows potential to treat multiple sclerosis, diabetes: Study

<div class="KonaFilter image-container display-table float_right"><div><div class="image on-image">Yuriko Nakao/ReutersA boy soaks himself in a hot bath incorporating curry spices at Hakone Kowakien,at the hot spring resort of Hakone, west of Tokyo July 21, 2006. The bath containing curry spices, such as red pepper and turmeric, improves blood flow and produce beautiful skin, the resort said.</div></div></div>FA Insights is a daily newsletter from Business Insider that delivers the top news and commentary for financial advisors.<a href="http://www.schwab.com/public/schwab/nn/articles/Japan-Another-Recession-Coming">Japan has a lot of problems</a> (Charles Schwab)Japan's economy is struggling again - even though the country has pursued aggressive monetary policies and has reaped the benefits of lower oil."Japan faces significant headwinds to growth including: a rising currency, the slowdown in China, a declining workforce, and ineffective monetary policy," writes Jeffrey Kleintop."Although Japanese stocks may see some relief if the yen stabilizes or reverses recent strength, we see the hefty headwinds offsetting the potential positives. Disappointment may be in store for those hoping for a sharp rebound in Japan's economic growth this year," he added.<a href="http://www.advisorperspectives.com/commentaries/20160517-gavekal-capital-apple-is-rebounding-today-but-we-wouldn-t-bite">Don't do something just because Buffett did it</a> (Advisor Perspectives)Berkshire Hathaway <a href="http://www.businessinsider.com/berkshire-hathaway-stake-in-apple-2016-5">owned $1 billion worth</a> of Apple shares as of the end of the first quarter. A regulatory filing out Monday from the Warren Buffett-led company showed the stake totaled 9.81 million shares at the time.However, "we believe that there are better options available than Apple at the moment," wrote Eric Bush of GaveKal Capital. "The reason why we wouldn't be quick to buy the dip in Apple is that the overall trend looks awful. There is really no other way to put it."<a href="http://www.investmentnews.com/gallery/20160513/FREE/513009999/PH/5-adviser-misconceptions-about-the-dol-fiduciary-rule">5 common misconceptions about the DOL fiduciary rule</a> (InvestmentNews)Tom Corra, the executive vice president and chief operating officer at Fidelity Clearing &amp; Custody Solutions, put together a list of misconceptions about the Department of Labor's fiduciary rule.Five common ones, he writes, are: 1) thinking you can continue business as usual, 2) thinking you can look to the DOL for direction on what to do, 3) thinking you can just use the BICE, 4) thinking you can just stay fee-only, and 5) thinking you can worry about this next year.<a href="http://www.bankrate.com/finance/consumer-index/financial-security-charts-0516.aspx">3 out of 4 Americans say they have financial regrets</a> (Bankrate.com)A new survey from Bankrate.com found that a staggering 75% of Americans say they have financial regrets. These respondents are most regretful about not saving enough for retirement (18%) and not saving enough for emergency expenses (13%)."Inadequate savings looms large among Americans' financial distress," said Bankrate.com Chief Financial Analyst Greg McBride, CFA. "Whether it's saving for emergencies or retirement, Americans' biggest financial regret is not saving enough." <a href="http://www.financial-planning.com/news/100m-adviser-departs-merrill-for-snowden-lane">A $100 million Merrill Lynch adviser jumps ship</a> (Financial Planning)Joseph Hubbell, an adviser who oversaw $100 million at Merrill Lynch, just left the firm to join Snowden Lane Partners. He will be merging his practice with that of two other former Merrill advisers. The team will rebrand as Veritas Private Wealth Group and oversee $370 million in client assets, reports Andrew Welsch. <div class="margin-top"> <h3>NOW WATCH: <a href="http://www.businessinsider.com/absolutely-everyone-needs-prenup-marriage-divorce-lisa-zeiderman-2015-12">Why absolutely everyone needs a prenup</a></h3> <div> <div> <div class="ooyala-video-player" data-video-autoplay="false" data-video-id="ttOGgweTp_ufF78dSmKnr_4eyRvQo7ih" data-player-variable="ooyalapopvideo" id="ooyalaplayer_popvideo" style="width:1280px;height:720px"></div> </div> </div> </div>

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New 'inverse vaccine' shows potential to treat multiple sclerosis, diabetes: Study

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Japan has a lot of problems

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