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(Eds: With file pics) Hyderabad, Two major vaccine makers from Hyderabad, <keyword id="1379126" type="General" weightage="20" keywordseo="Biological-E" source="Orion">Biological E</keyword> Ltd and <keyword id="149108" type="General" weightage="100" keywordseo="bharat-biotech" source="Orion">Bharat Biotech</keyword>, together are holding about 250 million doses of COVID-19 vaccines ready to dispatch as and when orders are received. According to respective company sources, Biological E is holding 200 million doses of its COVID-19 vaccine <keyword id="11370342" type="General" weightage="80" keywordseo="corbevax" source="Orion">Corbevax</keyword> while Bharat Biotech is sitting on a stockpile of 50 million doses of Covaxin. Dr Vikram Paradkar, Executive Vice President (Manufacturing), Biological E, said the firm produced about 30 crore doses of Corbevax in total, abiding by the vaccine manufacturing commitment to the Central government. In March '22, Biological E successfully supplied 10 crore doses to the government. "Currently, we have approximately 20 crore (200 million) doses that are fully tested and ready for supply, as and when we receive orders. Additionally, we manufactured 20 crore doses equivalent of the antigen which will help us ramp up the manufacturing of the Corbevax finished product quickly," Paradkar told PTI. The vaccine has been developed by Biological E in collaboration with Texas Children's Hospital Center for Vaccine Development (Texas Children's CVD) and Baylor College of Medicine (Baylor) in Houston, Texas, USA. He further said Biological E can begin with the additional vaccine supplies within eight weeks of future orders and can manufacture and supply approximately 10 crore doses of Corbevax on a monthly basis as per its qualified manufacturing capacity. Bharat Biotech sources said the vaccine maker has more than 50 million doses of Covaxin readily available in vials, and over 200 million doses as drug substance. "Additional production capacity is also available to meet product demand," they said adding fresh stocks of the vaccine are available and ready for supplies. Covaxin, India's indigenous COVID-19 vaccine, was developed in collaboration with the <keyword id="6364555" type="General" weightage="50" keywordseo="indian-council-of-medical-research" source="Orion">Indian Council of Medical Research</keyword> (ICMR) - National Institute of Virology (NIV). Due to lack of product demand, production stoppage of Covaxin was initiated earlier this year and also the 50 million doses in vials are set to expire during early 2023, resulting in losses to the company, sources had earlier said. SEE ALSO: <a href="https://www.businessinsider.in/india/news/rise-in-active-covid-19-cases-in-bihar-no-need-for-panic-says-expert/articleshow/96561025.cms">Rise in active COVID-19 cases in Bihar; no need for panic, says expert</a> <a href="https://www.businessinsider.in/science/health/news/covid-19-nasal-vaccine-bharat-biotechs-incovacc-is-the-first-approved-intranasal-vaccine-in-the-world/slidelist/96542239.cms">All you need to know about the world’s first Covid-19 nasal vaccine - iNCOVACC</a>

Biological E, Bharat Biotech together sitting on stockpile of 250 million COVID vaccine doses

<keyword id="1379126" type="General" weightage="20" keywordseo="Biological-E" source="Orion">Biological E</keyword>. Limited, whose <keyword id="11370342" type="General" weightage="100" keywordseo="corbevax" source="Orion">Corbevax</keyword> on Tuesday received the approval from the Drugs Controller General of India (DGCI), plans to produce 75 million doses per month and anticipates over 100 million doses per month from February 2022. The Hyderabad-based company said these capacities will enable it to deliver 300 million doses as promised to the Government of India. Soon, the company plans to deliver more than one billion additional doses globally. Corbevax, India's first indigenously developed protein sub-unit vaccine against Covid-19, has been developed by Biological E in collaboration with Texas Children's Hospital Center for Vaccine Development (Texas Children's CVD) and Baylor College of Medicine (Baylor) in Houston, Texas. The vaccine will be effective both in scale and affordability, providing sustainable access to low-and middle-income countries, the vaccine maker said. "Our scientists at Texas Children's Hospital and Baylor College of Medicine are thrilled to help in the development of this vaccine, possibly the first Covid vaccine specifically designed for global health," said Dr. Peter Hotez, professor and dean of the National School of Tropical Medicine at Baylor and co-director of the Texas Children's Hospital Centre for Vaccine Development. "Over the years, we have worked to make quality vaccines and pharmaceutical products accessible to families around the world. With this as our backdrop, we resolved to develop an affordable and effective Covid-19 vaccine. It has now become a reality," said Mahima Datla, Managing Director, Biological E. Limited. Corbevax has completed two Phase III clinical trials involving more than 3,000 subjects between the ages of 18 and 80 at 33 study sites across India. The vaccine was found to be safe, well tolerated and immunogenic. Corbevax is a "recombinant protein sub-unit" vaccine, developed from the receptor binding domain (RBD) of the spike protein on the virus's surface combined with Dynavax's CpG 1018 adjuvant with alum, which helps the body build the immune response against the virus. "In the pivotal Phase III study conducted with an endpoint of immunogenic superiority, Corbevax demonstrated superior immune response in comparison with Covishield vaccine when assessed for Neutralising Antibody (nAb) Geometric Mean Titers (GMT) against the Ancestral-Wuhan strain and the globally dominant Delta variant. Corbevax vaccination also generated a significant Th1 skewed cellular immune response," Biological E said. According to the vaccine-maker, Corbevax nAb GMT against Ancestral-Wuhan strain is indicative of vaccine effectiveness of more than 90 per cent for prevention of symptomatic infections based on the Correlates of Protection assessment performed during Moderna and Astra-Zeneca vaccine Phase III studies. Against the Delta strain, it indicates a vaccine effectiveness of more than 80 per cent for the prevention of symptomatic infections based on published studies. While none of the subjects who took Corbevax or Covishield had serious adverse events, Corbevax had 50 per cent fewer adverse events than Covishield. SEE ALSO: <a href="https://www.businessinsider.in/india/news/govt-panel-allows-emergency-use-of-mercks-new-drug-molnupiravir-for-treatment-of-mild-to-moderate-covid-19-cases/articleshow/88536179.cms">India allows emergency use of Merck's new drug Molnupiravir for treatment of mild-to-moderate COVID-19 cases</a>

Biological E to produce 100 million doses of Corbevax Covid vaccine from February 2022

The Drugs Controller General of <keyword id="3658" type="General" weightage="50" keywordseo="india" source="Orion">India</keyword> (DCGI) on Tuesday approved the restricted emergency use authorisation (EUA) to Bharat Biotech's Covaxin for children between the age of 6-12 years, sources said. The <keyword id="704367" type="General" weightage="50" keywordseo="dgci" source="Orion">DGCI</keyword> has asked vaccine manufacturer to submit safety data including the data on adverse event with due analysis every 15 days for the first two months and monthly thereafter upto 5 months, said the source familiar with the development. This development comes after the <keyword id="3923779" type="General" weightage="50" keywordseo="subject-expert-committee" source="Orion">Subject Expert Committee</keyword> (<keyword id="6362470" type="General" weightage="80" keywordseo="sec" source="Orion">SEC</keyword>) discussed recommendations for the restricted emergency use of Covaxin in children aged between 2-12 years. However, the SEC, after a meeting on Thursday, had recommended restricted emergency use of Biological E's Covid-19 vaccine, Corbevax, in children aged 5-12 years. SEE ALSO: <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/politics/india/news/real-time-payments-are-forecast-to-boost-indian-gdp-by-us-45-9-billion-in-2026/articleshow/91093163.cms">Real-time payments are forecast to boost Indian GDP by US $45.9 billion in 2026</a> <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/science/health/news/25-40-of-people-with-covid-19-develop-long-covid-reporting-symptoms-that-affect-multiple-organs-and-cause-mental-health-issues-study/articleshow/91093962.cms">25-40% of people with COVID-19 develop long Covid, reporting symptoms that affect organs and cause mental health issues : Study</a>

DCGI gives nod to Bharat Biotech's Covaxin for 6-12 age group in India

The increase in number of dengue cases, ahead of the monsoon season, has put <keyword id="6354750" type="General" weightage="80" keywordseo="health" source="Orion">health</keyword> officials in <keyword id="6357713" type="General" weightage="80" keywordseo="uttar-pradesh" source="Orion">Uttar Pradesh</keyword> on alert. The state's Director General, Health, Vedvrata Singh said that Uttar Pradesh has the required medical infrastructure to counter the outbreak of dengue but the key to prevention was in the hands of the people. "There are 70 labs in the state with the facility of dengue testing at the moment and another 88 labs are being developed. Rapid Response (RR) teams have been formed at the block level who will take immediate action. Earlier such teams existed at the district level. At the same time, fever health desks have been established in every hospital," he said. Director, Communicable Diseases, A.K. Singh said that there is neither any medicine nor any vaccine for dengue and therefore, efforts should be made to prevent the mosquito bite. Even if the disease affects a person, recovery under medical supervision is possible, he noted. <keyword id="13953621" type="General" weightage="80" keywordseo="vikas-singhal" source="Orion">Vikas Singhal</keyword>, Joint Director, <keyword id="520601" type="General" weightage="50" keywordseo="vector-borne-diseases" source="Orion">Vector Borne Diseases</keyword> (<keyword id="313015" type="General" weightage="50" keywordseo="vbd" source="Orion">VBD</keyword>), said that people usually take fever lightly which costs them dearly. "If the fever persists, the patient should get tested for dengue. Upon diagnosis, high fluid diet should be taken along with medicines," he said, adding that patients should be saved from dehydration. Additional Director, Malaria Control, R.C. Pandey said that dengue can be stopped by united efforts by government, civic agencies and people. SEE ALSO: <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/science/health/news/india-starts-testing-flu-patients-selectively-as-covid-numbers-plateau/articleshow/91610431.cms">India starts testing flu patients ‘selectively’ as COVID numbers plateau</a> <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/india/news/corbevax-price-slashed-to-250-per-dose-inclusive-of-gst/articleshow/91598556.cms">Corbevax price slashed to ₹250 per dose inclusive of GST</a>

Rising dengue cases in Uttar Pradesh put health officials on high alert

<ul class="summary-list"><li>Public health experts have previously said <keyword id="11894310" type="UNKNOWN" weightage="60" keywordseo="vaccine" source="Orion">vaccine</keyword> inequality would allow for new variants. </li><li>A Texas doctor and his team developed Corbevax, a low-cost COVID-19 vaccine. </li></ul>A Texas pediatrician and a professor developed a low-cost COVID-19 vaccine that was approved for emergency use in <keyword id="11892747" type="UNKNOWN" weightage="60" keywordseo="india" source="Orion">India</keyword> on Tuesday. Dr. Peter Hotez, a pediatrician at Texas Children's Hospital, developed the Corbevax vaccine alongside Baylor College professor Dr. Maria Elena Bottazzi, <a href="https://www.texaschildrens.org/texas-children%E2%80%99s-hospital-and-baylor-college-medicine-covid-19-vaccine-technology-secures-emergency">a press release from the children's hospital said. </a>"This announcement is an important first step in vaccinating the world and halting the pandemic," Hotez said. The vaccine, which the developers called the "World's COVID-19 Vaccine," uses a traditional recombinant protein-based technology, which would allow it to be mass-produced and used across the globe. "Protein-based vaccines have been widely used to prevent many other diseases, have proven safety records, and use economies of scale to achieve low-cost scalability across the world," Bottazzi said.According to the press release, the vaccine's initial construct and production was developed at Texas Children's Hospital and then licensed from the Baylor College of Medicine to Biological E. Limited, a Hyderabad-based vaccine, and pharmaceutical company. Hotez said in a <a href="https://twitter.com/PeterHotez/status/1475838570883690499">tweet</a> that Biological E. already has 150 million doses ready and will be making 100 million doses a month. The vaccine was found to be safe and effective after two phase 3 clinical trials of more than 3,000 participants, the press release said. The low-cost vaccine is meant to help<a href="https://www.businessinsider.com/new-coronavirus-variant-may-be-result-of-vaccine-inequality-2021-11"> low and middle-income countries</a>, access vaccines, the press release said. "Widespread and global vaccination with our Texas Children's-Baylor-BE vaccine would also forestall the emergence of new variants. We have previously missed that opportunity for the alpha and delta variant. Now is our chance to prevent a new global wave from what might follow," Hotez said. The announcement comes as the <a href="https://www.businessinsider.com/how-long-does-booster-protection-omicron-covid-last-study-2021-12">Omicron variant</a> spreads across the globe. The variant is believed to be more transmissible than previous variants. So far, there have been more than 282 million COVID-19 cases across the globe, according to data from Johns Hopkins University. Experts have previously warned that rich countries hoarding vaccines and the lack of access in poorer countries could allow for new variants to emerge. While more than 48% of the world population has been fully vaccinated, wealthier countries <a href="https://ourworldindata.org/covid-vaccinations?country=OWID_WRL">like the US and UK have a significantly higher rate of doses administered per 100 people. </a>Ken Shadlen, a professor of development studies at the London School of Economics and Political <keyword id="11896083" type="UNKNOWN" weightage="100" keywordseo="science" source="Orion">Science</keyword>, <a href="https://www.businessinsider.com/rich-nations-hoarding-covid-19-vaccines-could-backfire-experts-say-2021-3?r=US&amp;IR=T">told Insider's Sinéad Baker</a> in March that if global vaccine inequality persists "it's going to potentially undermine the health benefits of all that we're doing with lockdowns and vaccines."The vaccine's authorization was praised by Texas politicians, including former presidential candidate Beto O'Rourke. "Making Texas proud!" O'Rourke <a href="https://twitter.com/BetoORourke/status/1475909362736631810">said</a> of Hotez's team. <a href="https://t.co/zMnxgBveZz" target="_blank" rel="noopener noreferrer"></a>In a <a href="https://twitter.com/PeterHotez/status/1475839914910666767?s=20">tweet</a>, Hotez added that the children's hospital does not plan to profit from the vaccine, calling it a "gift to the world."He said the technology to develop the vaccine has already been transferred to producers in India, Indonesia, Bangladesh, and Botswana.Hotez did not respond to Insider's request for comment at the time of publication.

A Texas pediatrician and professor developed a low-cost COVID-19 vaccine. India just granted it emergency use authorization.

Micro-blogging site <keyword id="6354616" type="General" weightage="20" keywordseo="twitter" source="Orion">Twitter</keyword> is reportedly testing a new way to untag for users who do not wish to be part of a thread. A writer and researcher Machun Wong in a new Tweet revealed insight into how this feature will be helpful. The feature would untag username from a Twitter conversation, preventing people from mentioning it in the conversation again. The user will also not receive notifications from the conversation, but will still have access to it. In the screenshot, there is a popup window that outlines what this feature will do, giving the user the option to choose it or decline it. Meanwhile, Twitter has started rolling out pinned direct messages to everyone on Android, iOS, and the web. Twitter is now rolling out a feature to pin up to six conversations, which will then always appear above your other messages. To pin a conversation on the best Android phones, you just need to press and hold the message you want to save. "Pin Conversation" is expected to appear above other options. On the web, the option will appear via the three-dot menu when you hover over a conversation in your inbox. Twitter is also rolling out its new bot labels that will let bot accounts to include a label to show they are automated. SEE ALSO <a class="tout-title-link" href="https://www.businessinsider.in/stock-market/news/equity-markets-across-the-world-witness-bloodbath-amid-worsening-russia-ukraine-conflict/articleshow/89740850.cms">Equity markets across the world witness bloodbath amid worsening Russia-Ukraine conflict</a> <a href="https://www.businessinsider.in/science/health/news/corbevax-and-zycov-d-things-to-keep-in-mind-before-taking-your-kids-for-covid-19-vaccination/articleshow/89739808.cms" data-type="tilCustomLink">Corbevax and ZyCoV-D – Things to keep in mind before taking your kids for COVID-19 vaccination</a> <a href="https://www.businessinsider.in/stock-market/news/vedanta-reliance-airtel-and-other-hot-stocks-on-february-22-as-russia-ukraine-crisis-spooks-global-markets/slidelist/89737976.cms">Vedanta, Reliance, Airtel and other hot stocks on February 22 as Russia-Ukraine crisis spooks global markets</a>

Twitter may let you untag yourself from threads

<keyword id="6358777" type="General" weightage="20" keywordseo="new-delhi" source="Orion">New Delhi</keyword>, March 14 (IANS) The <keyword id="6362177" type="General" weightage="20" keywordseo="union-government" source="Orion">Union Government</keyword> after deliberations with scientific bodies decided on Monday to start <keyword id="9257042" type="General" weightage="20" keywordseo="covid-vaccination" source="Orion">Covid vaccination</keyword> for 12-14 year age group from March 16. Those teenagers born in 2008, 2009 and 2010 or those who are already above 12 years of age of population will be administered <keyword id="8764262" type="General" weightage="100" keywordseo="covid" source="Orion">Covid</keyword> vaccines from March 16. The Covid-19 vaccine to be administered would be Corbevax manufactured by Hyderabad based Biological E, said the <keyword id="83655" type="General" weightage="20" keywordseo="union-health-ministry" source="Orion">Union Health Ministry</keyword>. The government has also decided that the condition of co-morbidity for Covid-19 precaution dose for population over 60 years of age will be removed forthwith. "If children are safe then the country is safe! I am happy to inform that the Covid vaccination program for the children in the age group of 12 to 13 and 13 to 14 is starting from March 16", said Union Health Minister Mansukh Mandaviya in a tweet. "Also, everyone aged 60 plus will now be able to get precaution dose. I urge the families of children and people in the age group of 60 plus that they must get the vaccine", he said in the same tweet in Hindi. The ministry said that the population above 14 years of age is already being administered vaccines under the ongoing vaccination drive. "Hence, from 16th March 2022 onwards, the entire population above 60 years of age will be eligible for Precaution Dose of COVID19 vaccine", said the ministry. SEE ALSO: <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/politics/india/news/india-records-the-lowest-single-day-covid-19-spike-only-2503-cases-in-680-days/articleshow/90195533.cms">India records the lowest single-day COVID-19 spike, only 2,503 cases in 680 days</a> <a href="https://www.businessinsider.in/stock-market/news/paytms-shares-hit-an-all-time-low-plunging-below-the-700-mark-after-rbi-pulls-up-its-payments-bank/articleshow/90193957.cms">Paytm’s shares hit an all-time low plunging below the ₹700-mark after RBI pulls up its payments bank</a>

You Searched For "corbevax" and got 7 results

Biological E, Bharat Biotech together sitting on stockpile of 250 million COVID vaccine doses

PTI

Biological E to produce 100 million doses of Corbevax Covid vaccine from February 2022

IANS

DCGI gives nod to Bharat Biotech's Covaxin for 6-12 age group in India

IANS

Rising dengue cases in Uttar Pradesh put health officials on high alert

IANS

A Texas pediatrician and professor developed a low-cost COVID-19 vaccine. India just granted it emergency use authorization.

Sarah Al-Arshani

Twitter may let you untag yourself from threads

IANS

India to begin COVID-19 vaccination for kids aged 12 to 14 from Wednesday

IANS

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